caa a22 4500 528785508 20190908091347.0 cr unu---uuuuu 180924e201501 xx s 000 0 eng 10.3929/ethz-b-000098273 doi 10.7554/eLife.05055 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/98273 The contrasting phylodynamics of human influenza B viruses [Elektronische Daten] [Dhanasekaran Vijaykrishna, Edward C. Holmes, Udayan Joseph, Mathieu Fourment, Yvonne C.F. Su, Rebecca A. Halpin, Raphael T.C. Lee, Yi-Mo Deng, Vithiagaran Gunalan, Xudong Lin, Timothy B. Stockwell, Nadia B. Fedorova, Bin Zhou, Natalie Spirason, Denise Kühnert, Veronika Boskova, Tanja; id_orcid 0000-0001-6431-535X Stadler, Anna-Maria Costa, Dominic E. Dwyer, Q. Sue Huang, Lance C. Jennings, William Rawlinson, Sheena G. Sullivan, Aeron C. Hurt, Sebastian Maurer-Stroh, David E. Wentworth, Gavin J.D. Smith, Ian G. Barr] Open access ethresearch A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Vijaykrishna Dhanasekaran joint author Holmes Edward C. joint author Joseph Udayan joint author Fourment Mathieu joint author Su Yvonne C.F. joint author Halpin Rebecca A. joint author Lee Raphael T.C. joint author Deng Yi-Mo joint author Gunalan Vithiagaran joint author Lin Xudong joint author Stockwell Timothy B. joint author Fedorova Nadia B. joint author Zhou Bin joint author Spirason Natalie joint author Kühnert Denise joint author Boskova Veronika joint author Stadler Tanja; id_orcid 0000-0001-6431-535X joint author Costa Anna-Maria joint author Dwyer Dominic E. joint author Huang Q. Sue joint author Jennings Lance C. joint author Rawlinson William joint author Sullivan Sheena G. joint author Hurt Aeron C. joint author Maurer-Stroh Sebastian joint author Wentworth David E. joint author Smith Gavin J.D. joint author Barr Ian G. joint author eLife Cambridge : eLife Sciences Publications 4, p. e05055 2050-084X http://hdl.handle.net/20.500.11850/98273 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/98273 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Vijaykrishna Dhanasekaran joint author ETHRESEARCH 700 1- Holmes Edward C. joint author ETHRESEARCH 700 1- Joseph Udayan joint author ETHRESEARCH 700 1- Fourment Mathieu joint author ETHRESEARCH 700 1- Su Yvonne C.F. joint author ETHRESEARCH 700 1- Halpin Rebecca A. joint author ETHRESEARCH 700 1- Lee Raphael T.C. joint author ETHRESEARCH 700 1- Deng Yi-Mo joint author ETHRESEARCH 700 1- Gunalan Vithiagaran joint author ETHRESEARCH 700 1- Lin Xudong joint author ETHRESEARCH 700 1- Stockwell Timothy B. joint author ETHRESEARCH 700 1- Fedorova Nadia B. joint author ETHRESEARCH 700 1- Zhou Bin joint author ETHRESEARCH 700 1- Spirason Natalie joint author ETHRESEARCH 700 1- Kühnert Denise joint author ETHRESEARCH 700 1- Boskova Veronika joint author ETHRESEARCH 700 1- Stadler Tanja; id_orcid 0000-0001-6431-535X joint author ETHRESEARCH 700 1- Costa Anna-Maria joint author ETHRESEARCH 700 1- Dwyer Dominic E. joint author ETHRESEARCH 700 1- Huang Q. Sue joint author ETHRESEARCH 700 1- Jennings Lance C. joint author ETHRESEARCH 700 1- Rawlinson William joint author ETHRESEARCH 700 1- Sullivan Sheena G. joint author ETHRESEARCH 700 1- Hurt Aeron C. joint author ETHRESEARCH 700 1- Maurer-Stroh Sebastian joint author ETHRESEARCH 700 1- Wentworth David E. joint author ETHRESEARCH 700 1- Smith Gavin J.D. joint author ETHRESEARCH 700 1- Barr Ian G. joint author ETHRESEARCH 773 0- eLife Cambridge : eLife Sciences Publications 4, p. e05055 2050-084X BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access