NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. Elegans
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528785605 | ||
| 005 | 20190908091347.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924e201701 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000128430 |2 doi |
| 024 | 7 | 0 | |a 10.7554/eLife.19493 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/128430 | ||
| 245 | 0 | 0 | |a NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. Elegans |h [Elektronische Daten] |c [Collin Ewald, id_orcid 0000-0003-1166-4171, John M. Hourihan, Monet S. Bland, Carolin Obieglo, Iskra Katic, Lorenza E.M. Mazzeo, Joy Alcedo, T. Keith Blackwell, Nancy E. Hynes] |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and thereby regulate many cellular processes, but their role in aging remains unexplored. Here, we identified the C. elegans orthologue of mammalian mediator of ErbB2-driven cell motility, MEMO-1, as a protein that inhibits BLI-3/NADPH oxidase. MEMO-1 is complexed with RHO-1/RhoA/GTPase and loss of memo-1 results in an enhanced interaction of RHO-1 with BLI-3/NADPH oxidase, thereby stimulating ROS production that signal via p38 MAP kinase to the transcription factor SKN-1/NRF1,2,3 to promote stress resistance and longevity. Either loss of memo-1 or increasing BLI-3/NADPH oxidase activity by overexpression is sufficient to increase lifespan. Together, these findings demonstrate that NADPH oxidase-induced redox signaling initiates a transcriptional response that protects the cell and organism, and can promote both stress resistance and longevity. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Ewald |D Collin |e joint author | |
| 700 | 0 | |a id_orcid 0000-0003-1166-4171 |e joint author | |
| 700 | 1 | |a Hourihan |D John M. |e joint author | |
| 700 | 1 | |a Bland |D Monet S. |e joint author | |
| 700 | 1 | |a Obieglo |D Carolin |e joint author | |
| 700 | 1 | |a Katic |D Iskra |e joint author | |
| 700 | 1 | |a Mazzeo |D Lorenza E.M. |e joint author | |
| 700 | 1 | |a Alcedo |D Joy |e joint author | |
| 700 | 1 | |a Blackwell |D T. Keith |e joint author | |
| 700 | 1 | |a Hynes |D Nancy E. |e joint author | |
| 773 | 0 | |t eLife |d Cambridge : eLife Sciences Publications |g 6, p. e19493 |x 2050-084X | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/128430 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/128430 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Ewald |D Collin |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E -- |a id_orcid 0000-0003-1166-4171 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Hourihan |D John M. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Bland |D Monet S. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Obieglo |D Carolin |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Katic |D Iskra |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Mazzeo |D Lorenza E.M. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Alcedo |D Joy |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Blackwell |D T. Keith |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Hynes |D Nancy E. |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t eLife |d Cambridge : eLife Sciences Publications |g 6, p. e19493 |x 2050-084X | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||