Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528785761 | ||
| 005 | 20190713030955.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2014 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000094815 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms5352 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/94815 | ||
| 245 | 0 | 0 | |a Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network |h [Elektronische Daten] |c [Viktória Lázár, István Nagy, Réka Spohn, Bálint Csörgő, Ádám Györkei, Ákos Nyerges, Balázs Horváth, Andrea Vörös, Róbert Busa-Fekete, Mónica Hrtyan, Balazs; id_orcid 0000-0003-0253-7015 Bogos, Orsolya Méhi, Gergely Fekete, Balázs Szappanos, Balázs Kégl, Balázs Papp, Csaba Pál] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and explored the driving evolutionary principles. Here, we show that (1) convergent molecular evolution is prevalent across antibiotic treatments, (2) resistance conferring mutations simultaneously enhance sensitivity to many other drugs and (3) 27% of the accumulated mutations generate proteins with compromised activities, suggesting that antibiotic adaptation can partly be achieved without gain of novel function. By using knowledge on antibiotic properties, we examined the determinants of cross-resistance and identified chemogenomic profile similarity between antibiotics as the strongest predictor. In contrast, cross-resistance between two antibiotics is independent of whether they show synergistic effects in combination. These results have important implications on the development of novel antimicrobial strategies. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Lázár |D Viktória |e joint author | |
| 700 | 1 | |a Nagy |D István |e joint author | |
| 700 | 1 | |a Spohn |D Réka |e joint author | |
| 700 | 1 | |a Csörgő |D Bálint |e joint author | |
| 700 | 1 | |a Györkei |D Ádám |e joint author | |
| 700 | 1 | |a Nyerges |D Ákos |e joint author | |
| 700 | 1 | |a Horváth |D Balázs |e joint author | |
| 700 | 1 | |a Vörös |D Andrea |e joint author | |
| 700 | 1 | |a Busa-Fekete |D Róbert |e joint author | |
| 700 | 1 | |a Hrtyan |D Mónica |e joint author | |
| 700 | 1 | |a Bogos |D Balazs; id_orcid 0000-0003-0253-7015 |e joint author | |
| 700 | 1 | |a Méhi |D Orsolya |e joint author | |
| 700 | 1 | |a Fekete |D Gergely |e joint author | |
| 700 | 1 | |a Szappanos |D Balázs |e joint author | |
| 700 | 1 | |a Kégl |D Balázs |e joint author | |
| 700 | 1 | |a Papp |D Balázs |e joint author | |
| 700 | 1 | |a Pál |D Csaba |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 5, p. 4352 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/94815 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/94815 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Lázár |D Viktória |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Nagy |D István |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Spohn |D Réka |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Csörgő |D Bálint |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Györkei |D Ádám |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Nyerges |D Ákos |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Horváth |D Balázs |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Vörös |D Andrea |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Busa-Fekete |D Róbert |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Hrtyan |D Mónica |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Bogos |D Balazs; id_orcid 0000-0003-0253-7015 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Méhi |D Orsolya |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Fekete |D Gergely |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Szappanos |D Balázs |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kégl |D Balázs |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Papp |D Balázs |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Pál |D Csaba |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 5, p. 4352 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||