caa a22 4500 528785850 20190713030955.0 cr unu---uuuuu 180924s2015 xx s 000 0 eng 10.3929/ethz-b-000103748 doi 10.1038/ncomms9141 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/103748 Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice [Elektronische Daten] [Yen-Lin Huang, Christophe Chassard, Martin Hausmann, Mark Von Itzstein, Thierry Hennet] Nat Commun Open access ethresearch Rapid shifts in microbial composition frequently occur during intestinal inflammation, but the mechanisms underlying such changes remain elusive. Here we demonstrate that an increased caecal sialidase activity is critical in conferring a growth advantage for some bacteria including Escherichia coli (E. coli) during intestinal inflammation in mice. This sialidase activity originates among others from Bacteroides vulgatus, whose intestinal levels expand after dextran sulphate sodium administration. Increased sialidase activity mediates the release of sialic acid from intestinal tissue, which promotes the outgrowth of E. coli during inflammation. The outburst of E. coli likely exacerbates the inflammatory response by stimulating the production of pro-inflammatory cytokines by intestinal dendritic cells. Oral administration of a sialidase inhibitor and low levels of intestinal α2,3-linked sialic acid decrease E. coli outgrowth and the severity of colitis in mice. Regulation of sialic acid catabolism opens new perspectives for the treatment of intestinal inflammation as manifested by E. coli dysbiosis. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Huang Yen-Lin joint author Chassard Christophe joint author Hausmann Martin joint author Von Itzstein Mark joint author Hennet Thierry joint author Nature Communications London : Nature Publishing Group 6, p. 8141 2041-1723 http://hdl.handle.net/20.500.11850/103748 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/103748 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Huang Yen-Lin joint author ETHRESEARCH 700 1- Chassard Christophe joint author ETHRESEARCH 700 1- Hausmann Martin joint author ETHRESEARCH 700 1- Von Itzstein Mark joint author ETHRESEARCH 700 1- Hennet Thierry joint author ETHRESEARCH 773 0- Nature Communications London : Nature Publishing Group 6, p. 8141 2041-1723 SWISSBIB 341610887 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access