Hippocampal and prefrontal processing of network topology to simulate the future
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528786016 | ||
| 005 | 20190713030955.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2017 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000130108 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms14652 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/130108 | ||
| 245 | 0 | 0 | |a Hippocampal and prefrontal processing of network topology to simulate the future |h [Elektronische Daten] |c [Amir-Homayoun Javadi, Beatrix Emo, Lorelei R. Howard, Fiona E. Zisch, Yichao Yu, Rebecca Knight, Joao P. Silva, Hugo J. Spiers] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Javadi |D Amir-Homayoun |e joint author | |
| 700 | 1 | |a Emo |D Beatrix |e joint author | |
| 700 | 1 | |a Howard |D Lorelei R. |e joint author | |
| 700 | 1 | |a Zisch |D Fiona E. |e joint author | |
| 700 | 1 | |a Yu |D Yichao |e joint author | |
| 700 | 1 | |a Knight |D Rebecca |e joint author | |
| 700 | 1 | |a Silva |D Joao P. |e joint author | |
| 700 | 1 | |a Spiers |D Hugo J. |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 8, p. 14652 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/130108 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/130108 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Javadi |D Amir-Homayoun |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Emo |D Beatrix |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Howard |D Lorelei R. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Zisch |D Fiona E. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Yu |D Yichao |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Knight |D Rebecca |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Silva |D Joao P. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Spiers |D Hugo J. |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 8, p. 14652 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||