caa a22 4500 528786016 20190713030955.0 cr unu---uuuuu 180924s2017 xx s 000 0 eng 10.3929/ethz-b-000130108 doi 10.1038/ncomms14652 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/130108 Hippocampal and prefrontal processing of network topology to simulate the future [Elektronische Daten] [Amir-Homayoun Javadi, Beatrix Emo, Lorelei R. Howard, Fiona E. Zisch, Yichao Yu, Rebecca Knight, Joao P. Silva, Hugo J. Spiers] Nat Commun Open access ethresearch Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Javadi Amir-Homayoun joint author Emo Beatrix joint author Howard Lorelei R. joint author Zisch Fiona E. joint author Yu Yichao joint author Knight Rebecca joint author Silva Joao P. joint author Spiers Hugo J. joint author Nature Communications London : Nature Publishing Group 8, p. 14652 2041-1723 http://hdl.handle.net/20.500.11850/130108 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/130108 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Javadi Amir-Homayoun joint author ETHRESEARCH 700 1- Emo Beatrix joint author ETHRESEARCH 700 1- Howard Lorelei R. joint author ETHRESEARCH 700 1- Zisch Fiona E. joint author ETHRESEARCH 700 1- Yu Yichao joint author ETHRESEARCH 700 1- Knight Rebecca joint author ETHRESEARCH 700 1- Silva Joao P. joint author ETHRESEARCH 700 1- Spiers Hugo J. joint author ETHRESEARCH 773 0- Nature Communications London : Nature Publishing Group 8, p. 14652 2041-1723 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access