Sensitive detection of rare disease-Associated cell subsets via representation learning
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528786091 | ||
| 005 | 20190713030956.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2017 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000130442 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms14825 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/130442 | ||
| 100 | 1 | |a Arvaniti |D Eirini | |
| 245 | 1 | 0 | |a Sensitive detection of rare disease-Associated cell subsets via representation learning |h [Elektronische Daten] |c [Eirini Arvaniti, Manfred Claassen] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to detect rare cell subsets associated with disease using high-dimensional single-cell measurements. Using CellCnn, we identify paracrine signalling-, AIDS onset- and rare CMV infection-associated cell subsets in peripheral blood, and extremely rare leukaemic blast populations in minimal residual disease-like situations with frequencies as low as 0.01%. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Claassen |D Manfred |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 8, p. 14825 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/130442 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/130442 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 100 |E 1- |a Arvaniti |D Eirini | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Claassen |D Manfred |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 8, p. 14825 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||