Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528786385 | ||
| 005 | 20190713030957.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2015 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000105367 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms9490 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/105367 | ||
| 245 | 0 | 0 | |a Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain |h [Elektronische Daten] |c [Shuko Takeda, Susanne Wegmann, Hansang Cho, Sarah L. DeVos, Caitlin Commins, Allyson D. Roe, Samantha B. Nicholls, George A. Carlson, Rose Pitstick, Chloe K. Nobuhara, Isabel Costantino, Matthew P. Frosch, Daniel J.; id_orcid 0000-0003-3075-0665 Müller, Daniel Irimia, Bradley T. Hyman] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Tau pathology is known to spread in a hierarchical pattern in Alzheimer's disease (AD) brain during disease progression, likely by trans-synaptic tau transfer between neurons. However, the tau species involved in inter-neuron propagation remains unclear. To identify tau species responsible for propagation, we examined uptake and propagation properties of different tau species derived from postmortem cortical extracts and brain interstitial fluid of tau-transgenic mice, as well as human AD cortices. Here we show that PBS-soluble phosphorylated high-molecular-weight (HMW) tau, though very low in abundance, is taken up, axonally transported, and passed on to synaptically connected neurons. Our findings suggest that a rare species of soluble phosphorylated HMW tau is the endogenous form of tau involved in propagation and could be a target for therapeutic intervention and biomarker development. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Takeda |D Shuko |e joint author | |
| 700 | 1 | |a Wegmann |D Susanne |e joint author | |
| 700 | 1 | |a Cho |D Hansang |e joint author | |
| 700 | 1 | |a DeVos |D Sarah L. |e joint author | |
| 700 | 1 | |a Commins |D Caitlin |e joint author | |
| 700 | 1 | |a Roe |D Allyson D. |e joint author | |
| 700 | 1 | |a Nicholls |D Samantha B. |e joint author | |
| 700 | 1 | |a Carlson |D George A. |e joint author | |
| 700 | 1 | |a Pitstick |D Rose |e joint author | |
| 700 | 1 | |a Nobuhara |D Chloe K. |e joint author | |
| 700 | 1 | |a Costantino |D Isabel |e joint author | |
| 700 | 1 | |a Frosch |D Matthew P. |e joint author | |
| 700 | 1 | |a Müller |D Daniel J.; id_orcid 0000-0003-3075-0665 |e joint author | |
| 700 | 1 | |a Irimia |D Daniel |e joint author | |
| 700 | 1 | |a Hyman |D Bradley T. |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 6, p. 8490 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/105367 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/105367 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Takeda |D Shuko |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Wegmann |D Susanne |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Cho |D Hansang |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a DeVos |D Sarah L. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Commins |D Caitlin |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Roe |D Allyson D. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Nicholls |D Samantha B. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Carlson |D George A. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Pitstick |D Rose |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Nobuhara |D Chloe K. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Costantino |D Isabel |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Frosch |D Matthew P. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Müller |D Daniel J.; id_orcid 0000-0003-3075-0665 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Irimia |D Daniel |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Hyman |D Bradley T. |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 6, p. 8490 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||