Mitotic redistribution of the mitochondrial network by Miro and Cenp-F
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528786407 | ||
| 005 | 20190713030957.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2015 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000103676 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms9015 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/103676 | ||
| 245 | 0 | 0 | |a Mitotic redistribution of the mitochondrial network by Miro and Cenp-F |h [Elektronische Daten] |c [Gil Kanfer, Thibault Courtheoux, Martin Peterka, Sonja Meier, Martin Soste, Andre Melnik, Katarina Reis, Pontus Aspenström, Matthias Peter, Paola Picotti, Benoît Kornmann] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Kanfer |D Gil |e joint author | |
| 700 | 1 | |a Courtheoux |D Thibault |e joint author | |
| 700 | 1 | |a Peterka |D Martin |e joint author | |
| 700 | 1 | |a Meier |D Sonja |e joint author | |
| 700 | 1 | |a Soste |D Martin |e joint author | |
| 700 | 1 | |a Melnik |D Andre |e joint author | |
| 700 | 1 | |a Reis |D Katarina |e joint author | |
| 700 | 1 | |a Aspenström |D Pontus |e joint author | |
| 700 | 1 | |a Peter |D Matthias |e joint author | |
| 700 | 1 | |a Picotti |D Paola |e joint author | |
| 700 | 1 | |a Kornmann |D Benoît |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 6, p. 8015 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/103676 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/103676 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kanfer |D Gil |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Courtheoux |D Thibault |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Peterka |D Martin |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Meier |D Sonja |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Soste |D Martin |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Melnik |D Andre |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Reis |D Katarina |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Aspenström |D Pontus |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Peter |D Matthias |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Picotti |D Paola |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kornmann |D Benoît |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 6, p. 8015 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||