caa a22 4500 528786407 20190713030957.0 cr unu---uuuuu 180924s2015 xx s 000 0 eng 10.3929/ethz-b-000103676 doi 10.1038/ncomms9015 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/103676 Mitotic redistribution of the mitochondrial network by Miro and Cenp-F [Elektronische Daten] [Gil Kanfer, Thibault Courtheoux, Martin Peterka, Sonja Meier, Martin Soste, Andre Melnik, Katarina Reis, Pontus Aspenström, Matthias Peter, Paola Picotti, Benoît Kornmann] Nat Commun Open access ethresearch Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Kanfer Gil joint author Courtheoux Thibault joint author Peterka Martin joint author Meier Sonja joint author Soste Martin joint author Melnik Andre joint author Reis Katarina joint author Aspenström Pontus joint author Peter Matthias joint author Picotti Paola joint author Kornmann Benoît joint author Nature Communications London : Nature Publishing Group 6, p. 8015 2041-1723 http://hdl.handle.net/20.500.11850/103676 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/103676 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Kanfer Gil joint author ETHRESEARCH 700 1- Courtheoux Thibault joint author ETHRESEARCH 700 1- Peterka Martin joint author ETHRESEARCH 700 1- Meier Sonja joint author ETHRESEARCH 700 1- Soste Martin joint author ETHRESEARCH 700 1- Melnik Andre joint author ETHRESEARCH 700 1- Reis Katarina joint author ETHRESEARCH 700 1- Aspenström Pontus joint author ETHRESEARCH 700 1- Peter Matthias joint author ETHRESEARCH 700 1- Picotti Paola joint author ETHRESEARCH 700 1- Kornmann Benoît joint author ETHRESEARCH 773 0- Nature Communications London : Nature Publishing Group 6, p. 8015 2041-1723 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access