caa a22 4500 528786474 20190713030957.0 cr unu---uuuuu 180924s2016 xx s 000 0 eng 10.3929/ethz-b-000122636 doi 10.1038/ncomms13299 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/122636 A multi-marker association method for genome-wide association studies without the need for population structure correction [Elektronische Daten] [Jonas R. Klasen, Elke Barbez, Lukas Meier, Nicolai Meinshausen, Peter Bühlmann, Maarten Koornneef, Wolfgang Busch, Korbinian Schneeberger] Nat Commun Open access ethresearch All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a new GWA method, called Quantitative Trait Cluster Association Test (QTCAT), enabling simultaneous multi-marker associations while considering correlations between markers. With this, QTCAT overcomes the need for population structure correction and also reflects the polygenic nature of complex traits better than single-marker methods. Using simulated data, we show that QTCAT clearly outperforms linear mixed model approaches. Moreover, using QTCAT to reanalyse public human, mouse and Arabidopsis GWA data revealed nearly all known and some previously undetected associations. Following up on the most significant novel association in the Arabidopsis data allowed us to identify a so far unknown component of root growth. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Klasen Jonas R. joint author Barbez Elke joint author Meier Lukas joint author Meinshausen Nicolai joint author Bühlmann Peter joint author Koornneef Maarten joint author Busch Wolfgang joint author Schneeberger Korbinian joint author Nature Communications London : Nature Publishing Group 7, p. 13299 2041-1723 http://hdl.handle.net/20.500.11850/122636 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/122636 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Klasen Jonas R. joint author ETHRESEARCH 700 1- Barbez Elke joint author ETHRESEARCH 700 1- Meier Lukas joint author ETHRESEARCH 700 1- Meinshausen Nicolai joint author ETHRESEARCH 700 1- Bühlmann Peter joint author ETHRESEARCH 700 1- Koornneef Maarten joint author ETHRESEARCH 700 1- Busch Wolfgang joint author ETHRESEARCH 700 1- Schneeberger Korbinian joint author ETHRESEARCH 773 0- Nature Communications London : Nature Publishing Group 7, p. 13299 2041-1723 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access