A Coupled Discrete/Continuum Model for Describing Cancer-Therapeutic Transport in the Lung
| LEADER | naa a22 4500 | ||
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| 001 | 528787055 | ||
| 005 | 20180924065502.0 | ||
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| 008 | 180924e20120312xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000044889 |2 doi |
| 024 | 7 | 0 | |a 10.1371/journal.pone.0031966 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/44889 | ||
| 245 | 0 | 2 | |a A Coupled Discrete/Continuum Model for Describing Cancer-Therapeutic Transport in the Lung |h [Elektronische Daten] |c [Karin M. Erbertseder, Johannes Reichold, Bernd Flemisch, Patrick Jenny, Rainer Helmig] |
| 246 | 0 | |a PLoS ONE | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a We propose a computational simulation framework for describing cancer-therapeutic transport in the lung. A discrete vascular graph model (VGM) is coupled to a double-continuum model (DCM) to determine the amount of administered therapeutic agent that will reach the cancer cells. An alveolar cell carcinoma is considered. The processes in the bigger blood vessels (arteries, arterioles, venules and veins) are described by the VGM. The processes in the alveolar capillaries and the surrounding tissue are represented by a continuum approach for porous media. The system of equations of the coupled discrete/continuum model contains terms that account for degradation processes of the therapeutic agent, the reduction of the number of drug molecules by the lymphatic system and the interaction of the drug with the tissue cells. The functionality of the coupled discrete/continuum model is demonstrated in example simulations using simplified pulmonary vascular networks, which are designed to show-off the capabilities of the model rather than being physiologically accurate. | |
| 540 | |a Creative Commons Attribution 3.0 Unported |u http://creativecommons.org/licenses/by/3.0 |2 ethresearch | ||
| 700 | 1 | |a Erbertseder |D Karin M. |e joint author | |
| 700 | 1 | |a Reichold |D Johannes |e joint author | |
| 700 | 1 | |a Flemisch |D Bernd |e joint author | |
| 700 | 1 | |a Jenny |D Patrick |e joint author | |
| 700 | 1 | |a Helmig |D Rainer |e joint author | |
| 773 | 0 | |t PLoS ONE |d Lawrence, KS, USA : Public Library of Science |g 7 (3), p. e31966 |x 1932-6203 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/44889 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/44889 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Erbertseder |D Karin M. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Reichold |D Johannes |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Flemisch |D Bernd |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Jenny |D Patrick |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Helmig |D Rainer |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t PLoS ONE |d Lawrence, KS, USA : Public Library of Science |g 7 (3), p. e31966 |x 1932-6203 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||