naa a22 4500 528787055 20180924065502.0 cr unu---uuuuu 180924e20120312xx s 000 0 eng 10.3929/ethz-b-000044889 doi 10.1371/journal.pone.0031966 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/44889 A Coupled Discrete/Continuum Model for Describing Cancer-Therapeutic Transport in the Lung [Elektronische Daten] [Karin M. Erbertseder, Johannes Reichold, Bernd Flemisch, Patrick Jenny, Rainer Helmig] PLoS ONE Open access ethresearch We propose a computational simulation framework for describing cancer-therapeutic transport in the lung. A discrete vascular graph model (VGM) is coupled to a double-continuum model (DCM) to determine the amount of administered therapeutic agent that will reach the cancer cells. An alveolar cell carcinoma is considered. The processes in the bigger blood vessels (arteries, arterioles, venules and veins) are described by the VGM. The processes in the alveolar capillaries and the surrounding tissue are represented by a continuum approach for porous media. The system of equations of the coupled discrete/continuum model contains terms that account for degradation processes of the therapeutic agent, the reduction of the number of drug molecules by the lymphatic system and the interaction of the drug with the tissue cells. The functionality of the coupled discrete/continuum model is demonstrated in example simulations using simplified pulmonary vascular networks, which are designed to show-off the capabilities of the model rather than being physiologically accurate. Creative Commons Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0 ethresearch Erbertseder Karin M. joint author Reichold Johannes joint author Flemisch Bernd joint author Jenny Patrick joint author Helmig Rainer joint author PLoS ONE Lawrence, KS, USA : Public Library of Science 7 (3), p. e31966 1932-6203 http://hdl.handle.net/20.500.11850/44889 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/44889 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Erbertseder Karin M. joint author ETHRESEARCH 700 1- Reichold Johannes joint author ETHRESEARCH 700 1- Flemisch Bernd joint author ETHRESEARCH 700 1- Jenny Patrick joint author ETHRESEARCH 700 1- Helmig Rainer joint author ETHRESEARCH 773 0- PLoS ONE Lawrence, KS, USA : Public Library of Science 7 (3), p. e31966 1932-6203 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access