The outer mucus layer hosts a distinct intestinal microbial niche
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| 008 | 180924s2015 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000104625 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms9292 |2 doi |
| 035 | |a (BORIS)oai:boris.unibe.ch:77343 | ||
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/104625 | ||
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| 245 | 0 | 4 | |a The outer mucus layer hosts a distinct intestinal microbial niche |h [Elektronische Daten] |c [Hai Li, Julien Periclis Jean Limenitakis, Tobias Fuhrer, Markus Geuking, Melissa A Lawson, Madeleine Wyss, Sandrine Brugiroux, Irene Keller, Jamie A Macpherson, Sandra Rupp, Bettina Stolp, Jens Volker Stein, Bärbel Stecher, Uwe Sauer, Kathleen McCoy, Andrew Macpherson] |
| 246 | 0 | |a Nat Commun | |
| 500 | |a publishedVersion | ||
| 506 | |a openAccess |2 eu-repo | ||
| 520 | 3 | |a The overall composition of the mammalian intestinal microbiota varies between individuals: within each individual there are differences along the length of the intestinal tract related to host nutrition, intestinal motility and secretions. Mucus is a highly regenerative protective lubricant glycoprotein sheet secreted by host intestinal goblet cells; the inner mucus layer is nearly sterile. Here we show that the outer mucus of the large intestine forms a unique microbial niche with distinct communities, including bacteria without specialized mucolytic capability. Bacterial species present in the mucus show differential proliferation and resource utilization compared with the same species in the intestinal lumen, with high recovery of bioavailable iron and consumption of epithelial-derived carbon sources according to their genome-encoded metabolic repertoire. Functional competition for existence in this intimate layer is likely to be a major determinant of microbiota composition and microbial molecular exchange with the host. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 700 | 1 | |a Li |D Hai |e joint author | |
| 700 | 1 | |a Limenitakis |D Julien Periclis Jean |e joint author | |
| 700 | 1 | |a Fuhrer |D Tobias |e joint author | |
| 700 | 1 | |a Geuking |D Markus |e joint author | |
| 700 | 1 | |a Lawson |D Melissa A. |e joint author | |
| 700 | 1 | |a Wyss |D Madeleine |e joint author | |
| 700 | 1 | |a Brugiroux |D Sandrine |e joint author | |
| 700 | 1 | |a Keller |D Irene |e joint author | |
| 700 | 1 | |a Macpherson |D Jamie A. |e joint author | |
| 700 | 1 | |a Rupp |D Sandra |e joint author | |
| 700 | 1 | |a Stolp |D Bettina |e joint author | |
| 700 | 1 | |a Stein |D Jens Volker |e joint author | |
| 700 | 1 | |a Stecher |D Bärbel |e joint author | |
| 700 | 1 | |a Sauer |D Uwe |e joint author | |
| 700 | 1 | |a McCoy |D Kathleen |e joint author | |
| 700 | 1 | |a Macpherson |D Andrew |e joint author | |
| 773 | 0 | |t Nature communications |g 6, p. 8292 | |
| 856 | 4 | 2 |
|z Onlinezugriff via WWW
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|u Li, Hai; Limenitakis, Julien Periclis Jean; Fuhrer, Tobias; Geuking, Markus; Lawson, Melissa A; Wyss, Madeleine; Brugiroux, Sandrine; Keller, Irene; Macpherson, Jamie A; Rupp, Sandra; Stolp, Bettina; Stein, Jens Volker; Stecher, Bärbel; Sauer, Uwe; McCoy, Kathleen; Macpherson, Andrew (2015). The outer mucus layer hosts a distinct intestinal microbial niche. Nature communications, 6, p. 8292. Nature Publishing Group 10.1038/ncomms9292 |
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| 949 | |B BORIS |F BORIS |b BORIS |j info:eu-repo/semantics/article |c openAccess | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||
| 950 |
|B BORIS
|P 856
|E 42
|z Onlinezugriff via WWW
|q text/html
|u Li, Hai; Limenitakis, Julien Periclis Jean; Fuhrer, Tobias; Geuking, Markus; Lawson, Melissa A; Wyss, Madeleine; Brugiroux, Sandrine; Keller, Irene; Macpherson, Jamie A; Rupp, Sandra; Stolp, Bettina; Stein, Jens Volker; Stecher, Bärbel; Sauer, Uwe; McCoy, Kathleen; Macpherson, Andrew (2015). The outer mucus layer hosts a distinct intestinal microbial niche. Nature communications, 6, p. 8292. Nature Publishing Group 10.1038/ncomms9292 |
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| 950 | |B BORIS |P 700 |E 1- |a Li |D Hai |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Limenitakis |D Julien Periclis Jean |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Fuhrer |D Tobias |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Geuking |D Markus |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Lawson |D Melissa A. |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Wyss |D Madeleine |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Brugiroux |D Sandrine |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Keller |D Irene |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Macpherson |D Jamie A. |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Rupp |D Sandra |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Stolp |D Bettina |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Stein |D Jens Volker |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Stecher |D Bärbel |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Sauer |D Uwe |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a McCoy |D Kathleen |e joint author | ||
| 950 | |B BORIS |P 700 |E 1- |a Macpherson |D Andrew |e joint author | ||
| 950 | |B BORIS |P 773 |E 0- |t Nature communications |g 6, p. 8292 | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/104625 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Li |D Hai |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Limenitakis |D Julien P. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Fuhrer |D Tobias |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Geuking |D Markus B. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Lawson |D Melissa A. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Wyss |D Madeleine |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Brugiroux |D Sandrine |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Keller |D Irene |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Macpherson |D Jamie A. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Rupp |D Sandra |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stolp |D Bettina |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stein |D Jens V. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stecher |D Bärbel |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Sauer |D Uwe; id_orcid 0000-0002-5923-0770 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a McCoy |D Kathy D. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Macpherson |D Andrew J. |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 6, p. 8292 |x 2041-1723 | ||