cam a22 5 4500 528996134 CHVBK 20201014163639.0 m d cr |n |||||||| 180926s2015 ja |||| s 0 0|eng d 101653811 DNLM 978-4-431-55166-9 978-4-431-55165-2 (print) 10.1007/978-4-431-55166-9 doi (SERSOL)ssj0001424568 (SERSOL)ssj0001491198 (WaSeSS)ssj0001424568 (WaSeSS)ssj0001491198 WaSeSS QP356.3 .P73 2015 2015 C-100 QU 55.7 MJN bicssc MED057000 bisacsh QP lcco 612.8042 23 Mochida Sumiko editor Presynaptic Terminals [Elektronische Daten] edited by Sumiko Mochida Tokyo Springer Japan Imprint: Springer 2015 1 online resource (XIV, 365 p. 35 illus., 33 illus. in color.) online resource text file PDF rda Includes bibliographical references and index. Preface -- Part 1 Overview -- 1 Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases (Sumiko Mochida) -- Part 2 Presynaptic Active Zone Proteins -- 2 Active Zone Assembly (Thomas Dresbach) -- 3 Network of Protein-Protein Interaction at the Presynaptic Active Zone (Toshihisa Ohtsuka) -- Part 3 Synaptic Vesicle Fusion.-4 Fusion Machinery: SNARE Protein Complex (Ira Milosevic and Jakob B. Sørensen).-5 Roles of Tomosyn in Neurotransmitter Release (Yasunori Yamamoto and Toshiaki Sakisaka).-6 Regulation of SNAREs: Complexin (Hiroshi Tokumaru).-7 The Synaptic Vesicle V-ATPase: A Regulatory Link Between Loading and Fusion? (Oussama El Far and Michael Seager).-8 Ca2+ Sensors: Synaptotagmins (Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, and Hideki Matsui).-9 Regulation of Active Zone Ca2+ Channels (Karina Leal and Sumiko Mochida) -- Part 4 Synaptic Vesicle Endocytosis -- 10 Endocytic Machinery at the Neuronal Synapse (Ira Milosevic) -- 11 Dynamin is a Key Molecule to Decode Action Potential Firing (Shota Tanifuji and Sumiko Mochida) -- Part 5 Synaptic Vesicle Refilling and Storage -- 12 Transport of Amino Acid Neurotransmitters Into Synaptic Vesicles (Shigeo Takamori) -- 13 Synapsins and Synaptic Vesicle Storage (Fabrizia C. Guarnieri, Fabio Benfenati, and Flavia Valtorta) -- Part 6 Synaptic Vesicle Pools -- 14 Synaptic Vesicle Pools: Classical and Emerging Roles (Sven Truckenbrodt and Silvio O. Rizzoli) -- BM Index. Lizenzbedingungen können den Zugang einschränken. License restrictions may limit access. This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons' signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals. Medicine Human physiology Neurosciences Neurochemistry Biochemistry Calcium Channels metabolism Presynaptic Terminals physiology Synapses physiology Synaptic Vesicles physiology Synaptic Transmission physiology Cell Physiological Processes Biochemistry (OCoLC)fst00831961 fast Human physiology (OCoLC)fst00963183 fast Medicine (OCoLC)fst01014893 fast Neurochemistry (OCoLC)fst01036329 fast Neurosciences (OCoLC)fst01036509 fast SpringerLink (Online service) Printed edition 9784431551652 https://link.springer.com/10.1007/978-4-431-55166-9 Uni Basel: Volltext https://link.springer.com/10.1007/978-4-431-55166-9 Uni Bern: Volltext BK020053 XK020053 XK020000 Springer Biomedical and Life Sciences eBooks 2015 English/International E-Books von 360MarcUpdates O'Reilly Safari Learning Platform: Academic edition Ebook Central All Subscribed Titles IDSBB A145 A145 145VT IDSBB B405 B405 405VT IDSBB A145 A145 145VT NELA1452007 IDSBB B405 B405 405VT NELB4051809 IDSBB 100 1- Mochida Sumiko editor IDSBB 710 2- SpringerLink (Online service) IDSBB 776 08 Printed edition 9784431551652 IDSBB 856 40 https://link.springer.com/10.1007/978-4-431-55166-9 Uni Basel: Volltext IDSBB 856 40 https://link.springer.com/10.1007/978-4-431-55166-9 Uni Bern: Volltext IDSBB 700 1- Mochida Sumiko editor IDSBB 856 40 https://learning.oreilly.com/library/view/~/9780124200548/?ar Uni Basel: Volltext IDSBB 856 40 https://ebookcentral.proquest.com/lib/unibern/detail.action?docID=1997675 Uni Bern: Volltext