naa a22 4500 530045869 CHVBK 20181024071132.0 cr unu---uuuuu 181024e201810 xx s 000 0 eng 10.1111/epi.14495 doi (SERVAL)BIB_0596C6B349E4 30159884 pmid 000446321100015 isiid SENSE registry for status epilepticus [Elektronische Daten] [C. Kellinghaus, A.O. Rossetti, E. Trinka, N. Lang, I. Unterberger, S. Rüegg, C. Tilz, Z. Uzelac, F. Rosenow] Evidence is scarce regarding the treatment of status epilepticus (SE). Only a few large randomized controlled trials have been published. Therefore, we set up a multicenter registry to prospectively document treatment practice in several different large hospitals in German-speaking countries. Over a period of more than 4years, we were able to document 1179 episodes of 1049 patients who were treated for SE in 1 of the 8 participating centers in Germany, Austria, and Switzerland. Median age was 70years. The most frequent etiology was remote (32%), followed by acute (31%), or a mixture of acute and remote factors (10%). Semiology was generalized convulsive in 44%, focal motor in 27%, and nonconvulsive in 30%. Only a few patients did not have relevant comorbidities. Median latency between SE onset and first treatment was 1hour (median). Three hundred ninety-three (32%) of the patients were treated within 30minutes after onset. The first treatment step consisted of benzodiazepines in more than 80%, and in levetiracetam in 15%. Five hundred eleven patients (49%) were refractory (defined as ongoing SE after application of benzodiazepine and 1 intravenous anticonvulsant). Further analysis of these registry data may be important for hypothesis generation and trial design for treatment of status epilepticus. Kellinghaus C. aut Rossetti A.O. aut Trinka E. aut Lang N. aut Unterberger I. aut Rüegg S. aut Tilz C. aut Uzelac Z. aut Rosenow F. aut Epilepsia 59 Suppl 2(2018-10), 150-154 59 Suppl 2<150-154 2018 59 Suppl 2 1 article serval SERVAL 700 1- Kellinghaus C. aut SERVAL 700 1- Rossetti A.O. aut SERVAL 700 1- Trinka E. aut SERVAL 700 1- Lang N. aut SERVAL 700 1- Unterberger I. aut SERVAL 700 1- Rüegg S. aut SERVAL 700 1- Tilz C. aut SERVAL 700 1- Uzelac Z. aut SERVAL 700 1- Rosenow F. aut SERVAL 773 0- Epilepsia 59 Suppl 2(2018-10), 150-154 59 Suppl 2<150-154 2018 59 Suppl 2 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article