caa a22 4500 530075911 CHVBK 20190303134438.0 cr unu---uuuuu 181025e20181018xx s 000 0 eng 10.1016/j.cell.2018.09.028 doi (SERVAL)BIB_4F128B526214 30340041 pmid 000447780800015 isiid The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study [Elektronische Daten] [D. Terburg, D. Scheggia, R. Triana Del Rio, F. Klumpers, A.C. Ciobanu, B. Morgan, E.R. Montoya, P.A. Bos, G. Giobellina, E.H. van den Burg, B. de Gelder, D.J. Stein, R. Stoop, J. van Honk] Rodent research delineates how the basolateral amygdala (BLA) and central amygdala (CeA) control defensive behaviors, but translation of these findings to humans is needed. Here, we compare humans with natural-selective bilateral BLA lesions to rats with a chemogenetically silenced BLA. We find, across species, an essential role for the BLA in the selection of active escape over passive freezing during exposure to imminent yet escapable threat (T &lt;sub&gt;imm&lt;/sub&gt; ). In response to T &lt;sub&gt;imm&lt;/sub&gt; , BLA-damaged humans showed increased startle potentiation and BLA-silenced rats demonstrated increased startle potentiation, freezing, and reduced escape behavior as compared to controls. Neuroimaging in humans suggested that the BLA reduces passive defensive responses by inhibiting the brainstem via the CeA. Indeed, T &lt;sub&gt;imm&lt;/sub&gt; conditioning potentiated BLA projections onto an inhibitory CeA pathway, and pharmacological activation of this pathway rescued deficient T &lt;sub&gt;imm&lt;/sub&gt; responses in BLA-silenced rats. Our data reveal how the BLA, via the CeA, adaptively regulates escape behavior from imminent threat and that this mechanism is evolutionary conserved across rodents and humans. Terburg D. aut Scheggia D. aut Triana Del Rio R. aut Klumpers F. aut Ciobanu A.C. aut Morgan B. aut Montoya E.R. aut Bos P.A. aut Giobellina G. aut van den Burg E.H. aut de Gelder B. aut Stein D.J. aut Stoop R. aut van Honk J. aut Cell 175/3(2018-10-18), 723-735.e16 175:3<723-735.e16 2018 175 1 article serval SERVAL 700 1- Terburg D. aut SERVAL 700 1- Scheggia D. aut SERVAL 700 1- Triana Del Rio R. aut SERVAL 700 1- Klumpers F. aut SERVAL 700 1- Ciobanu A.C. aut SERVAL 700 1- Morgan B. aut SERVAL 700 1- Montoya E.R. aut SERVAL 700 1- Bos P.A. aut SERVAL 700 1- Giobellina G. aut SERVAL 700 1- van den Burg E.H. aut SERVAL 700 1- de Gelder B. aut SERVAL 700 1- Stein D.J. aut SERVAL 700 1- Stoop R. aut SERVAL 700 1- van Honk J. aut SERVAL 773 0- Cell 175/3(2018-10-18), 723-735.e16 175:3<723-735.e16 2018 175 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article