naa a22 4500 530098040 20181026074610.0 cr unu---uuuuu 181026e20090925xx s 000 0 eng 10.3929/ethz-b-000019546 doi 10.1371/journal.pgen.1000663 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/298000 Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis [Elektronische Daten] [Aleksandra Erilova, Lynette Brownfield, Vivien Exner, Marisa Rosa, David Twell, Ortrun Mittelsten Scheid, Lars Hennig, Claudia Köhler] PLoS Genet Open access ethresearch Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block.” Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Erilova Aleksandra joint author Brownfield Lynette joint author Exner Vivien joint author Rosa Marisa joint author Twell David joint author Mittelsten Scheid Ortrun joint author Hennig Lars joint author Köhler Claudia joint author PLoS Genetics San Francisco, CA : Public Library of Science 5 (9), p. e1000663 1553-7390 http://hdl.handle.net/20.500.11850/298000 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/298000 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Erilova Aleksandra joint author ETHRESEARCH 700 1- Brownfield Lynette joint author ETHRESEARCH 700 1- Exner Vivien joint author ETHRESEARCH 700 1- Rosa Marisa joint author ETHRESEARCH 700 1- Twell David joint author ETHRESEARCH 700 1- Mittelsten Scheid Ortrun joint author ETHRESEARCH 700 1- Hennig Lars joint author ETHRESEARCH 700 1- Köhler Claudia joint author ETHRESEARCH 773 0- PLoS Genetics San Francisco, CA : Public Library of Science 5 (9), p. e1000663 1553-7390 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access