caa a22 4500 530098903 20181217030327.0 cr unu---uuuuu 181026e20160519xx s 000 0 eng 10.3929/ethz-b-000117040 doi 10.1038/srep26527 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/117040 Alteration of functional connectivity in autism spectrum disorder: effect of age and anatomical distance [Elektronische Daten] [Zhiliang Long, Xujun Duan, Dante Mantini, Huafu Chen] Sci Rep Open access ethresearch Autism spectrum disorder (ASD) is associated with disruption of local- and long-range functional connectivity (FC). The direction of those changes in FC (increase or decrease), however, is inconsistent across studies. Further, age-dependent changes of distance-specific FC in ASD remain unclear. In this study, we used resting-state functional magnetic resonance imaging data from sixty-four typical controls (TC) and sixty-four patients with ASD, whom we further classified into child (<11 years), adolescent (11-18 years) and adult cohorts (>18 years). Functional connectivity (FC) analysis was conducted at voxel level. We employed a three-way analysis of covariance on FC to conduct statistical analyses. Results revealed that patients with ASD had lower FC than TC in cerebellum, fusiform gyrus, inferior occipital gyrus and posterior inferior temporal gyrus. Significant diagnosis-by-distance interaction was observed in ASD patients with reduced short-range and long-range FC in posterior cingulate cortex and medial prefrontal cortex. Importantly, we found significant diagnosis-by-age-by-distance interaction in orbitofrontal cortex with short-range FC being lower in autistic children, but -to a less extent- higher in autistic adults. Our findings suggest a major role of connection length in development changes of FC in ASD. We hope our study will facilitate deeper understanding of the neural mechanisms underlying ASD. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch Ageing ethresearch Autism spectrum disorders (ASD) ethresearch Long Zhiliang joint author Duan Xujun joint author Mantini Dante joint author Chen Huafu joint author Scientific Reports London : Nature Publishing Group 6, p. 26527 2045-2322 http://hdl.handle.net/20.500.11850/117040 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/117040 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Long Zhiliang joint author ETHRESEARCH 700 1- Duan Xujun joint author ETHRESEARCH 700 1- Mantini Dante joint author ETHRESEARCH 700 1- Chen Huafu joint author ETHRESEARCH 773 0- Scientific Reports London : Nature Publishing Group 6, p. 26527 2045-2322 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access