naa a22 4500 530185113 CHVBK 20181026074443.0 cr unu---uuuuu 181026e20170330xx s 000 0 eng 10.1056/NEJMoa1700518 doi (SERVAL)BIB_7C01478D4BFC 28316279 pmid 000397624900005 isiid Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism [Elektronische Daten] [J.I. Weitz, AWA Lensing, M.H. Prins, R. Bauersachs, J. Beyer-Westendorf, H. Bounameaux, T.A. Brighton, A.T. Cohen, B.L. Davidson, H. Decousus, MCS Freitas, G. Holberg, A.K. Kakkar, L. Haskell, B. van Bellen, A.F. Pap, S.D. Berkowitz, P. Verhamme, P.S. Wells, P. Prandoni, A. Bianchi, T. Brighton, P. Carroll, B. Chong, S. Chunilal, P. Coughlin, J. Curnow, D. Jackson, H. Tran, C. Ward, M. Brodmann, P. Kyrle, P. Marschang, V. Petkov, P. Hainaut, P. Jordens, J. Vandekerkhof, P. Verhamme, J-C Wautrecht, J. Annichino-Bizzacchi, B. van Bellen, J. Correa, A. Cukier, A. Freire, A. Pereira, C. Porto, R. Sacilotto, A. Vasconcelos Costa, A. Della Siega, S. Dolan, G. Le Gal, P. Gross, S. Kahn, J. Kassis, M. Kovacs, Y. Pesant, B. Ritchie, S. Schulman, S. Shivakumar, S. Solymoss, S. Chang, R. Chen, Z. Chen, H. Chen, X. Dai, B. Fang, W. Fu, X. Gao, J. Huang, Y. Lai, L. Li, X. Li, Y. Li, J. Liu, S. Liu, W. Ma, S. Ni, Z. Qin, G. Shi, H. Tian, S. Wang, L. Wang, W. Xiao, K. Ying, G. Yu, Y. Yuan, J. Zhang, J. Zhang, X. Zhang, L. Zhang, L. Zhu, J. Chlumský, J. Chochola, M. Dunaj, K. Kovarova, P. Lang, P. Matoška, I. Podpera, R. Spacek, O. Stehlikova, J. Brønnum-Schou, K. Egstrup, G. Gislason, J. Jeppesen, O. May, H. Nielsen, H. Wiggers, A. Achkar, S. Aquilanti, Y. Benhamou, D. Brisot, A. Bura-Riviere, N. Castella, A. Elias, N. Falvo, E. Ferrari, P. Lacroix, I. Mahe, N. Meneveau, E. Messas, P. Mismetti, K. Montaclair, D. Mottier, T. Moumneh, N. Paleiron, F. Parent, G. Pernod, O. Sanchez, J. Schmidt, G. Simoneau, D. Stephan, B. Amann, R. Bauersachs, J. Beyer-Westendorf, E. Blessing, M. Czihal, C. Espinola-Klein, G. Kahrmann, M. Licka, A. Neumeister, S. Schellong, Z. Boda, K. Farkas, M. Gurzo, A. Katona, M. Riba, G. Sipos, K. Tóth, A. Braester, M. Elias, A. Gafter-Gvili, D. Gavish, O. Hussein, M. Lishner, E. Schiff, G. Spectre, I. Tzoran-Rozenthal, R. Zimlichman, W. Ageno, G. Agnelli, C. Bova, R. Garbelotto, A. Ghirarduzzi, D. Imberti, R. Pesavento, E. Porreca, A. Visonà, L. Flota Cervera, G. Llamas Esperón, D. Rodriguez-Gonzalez, L. Solis Morales, W. Boersma, H. ten Cate, F. Erdkamp, A. Grifioen-Keijzer, M. Marwijk Kooy, K. Meijer, S. Middeldorp, J. Swart-Heikens, M. Ten Wolde, P. Westerweel, I. Braithwaite, P. Harper, E. Merriman, P. Ockelford, G. Royle, M. Smith, W. Ghanima, P.M. Sandset, M. Abola, P. Chęciński, P. Grzelakowski, J. Lewczuk, B. Sobkowicz, W. Tomkowski, I. Abramov, P. Chechulov, A. Karpenko, I. Katelnitskiy, A. Kazakov, O. Makarova, E. Panchenko, E. Sergeeva, Y. Subbotin, I. Suchkov, M. Zeltser, D. Adler, J. Breedt, N. Fourie, R. Isaacs, B. Jacobson, H. Siebert, L. van Zyl, J-H Choi, S-M Kang, K-H Kim, H-S Kim, D-I Kim, S-K Min, K.H. Park, F. García-Bragado Dalmau, J. Gómez Cerezo, JCF Mirete, A. Riera, J. Del Toro, H. Eriksson, I. Torstensson, M. Banyai, I. Baumgartner, L. Mazzolai, D. Periard, M. Righini, D. Staub, C-E Chiang, K-M Chiu, P-Y Pai, P. Angchaisuksiri, K. Chansung, G. Öngen, E. Tuncay, R. Alikhan, I. Chetter, P. Kesteven, T. Nokes, K. Bauer, A. Comerota, D. Elias, D. Garcia, K. Gibson, D. Ginsberg, J. Jenkins, E. Kingsley, R. Lambert, R. Lyons, J. Pullman, V. Shah, S.W. Smith, R. Stein, V. Tapson, J. Walsh, T-F Wang, D. Do Loi, H. Do Quang, N. Pham] Although many patients with venous thromboembolism require extended treatment, it is uncertain whether it is better to use full- or lower-intensity anticoagulation therapy or aspirin. In this randomized, double-blind, phase 3 study, we assigned 3396 patients with venous thromboembolism to receive either once-daily rivaroxaban (at doses of 20 mg or 10 mg) or 100 mg of aspirin. All the study patients had completed 6 to 12 months of anticoagulation therapy and were in equipoise regarding the need for continued anticoagulation. Study drugs were administered for up to 12 months. The primary efficacy outcome was symptomatic recurrent fatal or nonfatal venous thromboembolism, and the principal safety outcome was major bleeding. A total of 3365 patients were included in the intention-to-treat analyses (median treatment duration, 351 days). The primary efficacy outcome occurred in 17 of 1107 patients (1.5%) receiving 20 mg of rivaroxaban and in 13 of 1127 patients (1.2%) receiving 10 mg of rivaroxaban, as compared with 50 of 1131 patients (4.4%) receiving aspirin (hazard ratio for 20 mg of rivaroxaban vs. aspirin, 0.34; 95% confidence interval [CI], 0.20 to 0.59; hazard ratio for 10 mg of rivaroxaban vs. aspirin, 0.26; 95% CI, 0.14 to 0.47; P&lt;0.001 for both comparisons). Rates of major bleeding were 0.5% in the group receiving 20 mg of rivaroxaban, 0.4% in the group receiving 10 mg of rivaroxaban, and 0.3% in the aspirin group; the rates of clinically relevant nonmajor bleeding were 2.7%, 2.0%, and 1.8%, respectively. The incidence of adverse events was similar in all three groups. Among patients with venous thromboembolism in equipoise for continued anticoagulation, the risk of a recurrent event was significantly lower with rivaroxaban at either a treatment dose (20 mg) or a prophylactic dose (10 mg) than with aspirin, without a significant increase in bleeding rates. (Funded by Bayer Pharmaceuticals; EINSTEIN CHOICE ClinicalTrials.gov number, NCT02064439 .). Weitz J.I. aut Lensing AWA aut Prins M.H. aut Bauersachs R. aut Beyer-Westendorf J. aut Bounameaux H. aut Brighton T.A. aut Cohen A.T. aut Davidson B.L. aut Decousus H. aut Freitas MCS aut Holberg G. aut Kakkar A.K. aut Haskell L. aut van Bellen B. aut Pap A.F. aut Berkowitz S.D. aut Verhamme P. aut Wells P.S. aut Prandoni P. aut Bianchi A. Brighton T. Carroll P. Chong B. Chunilal S. Coughlin P. Curnow J. Jackson D. Tran H. Ward C. Brodmann M. Kyrle P. Marschang P. Petkov V. Hainaut P. Jordens P. Vandekerkhof J. Verhamme P. Wautrecht J-C Annichino-Bizzacchi J. van Bellen B. Correa J. Cukier A. Freire A. Pereira A. Porto C. Sacilotto R. Vasconcelos Costa A. Della Siega A. Dolan S. Le Gal G. Gross P. Kahn S. Kassis J. Kovacs M. Pesant Y. Ritchie B. Schulman S. Shivakumar S. Solymoss S. Chang S. Chen R. Chen Z. Chen H. Dai X. Fang B. Fu W. Gao X. Huang J. Lai Y. Li L. Li X. Li Y. Liu J. Liu S. Ma W. Ni S. Qin Z. Shi G. Tian H. Wang S. Wang L. Xiao W. Ying K. Yu G. Yuan Y. Zhang J. Zhang X. Zhang L. Zhu L. Chlumský J. Chochola J. Dunaj M. Kovarova K. Lang P. Matoška P. Podpera I. Spacek R. Stehlikova O. Brønnum-Schou J. Egstrup K. Gislason G. Jeppesen J. May O. Nielsen H. Wiggers H. Achkar A. Aquilanti S. Benhamou Y. Brisot D. Bura-Riviere A. Castella N. Elias A. Falvo N. Ferrari E. Lacroix P. Mahe I. Meneveau N. Messas E. Mismetti P. Montaclair K. Mottier D. Moumneh T. Paleiron N. Parent F. Pernod G. Sanchez O. Schmidt J. Simoneau G. Stephan D. Amann B. Bauersachs R. Beyer-Westendorf J. Blessing E. Czihal M. Espinola-Klein C. Kahrmann G. Licka M. Neumeister A. Schellong S. Boda Z. Farkas K. Gurzo M. Katona A. Riba M. Sipos G. Tóth K. Braester A. Elias M. Gafter-Gvili A. Gavish D. Hussein O. Lishner M. Schiff E. Spectre G. Tzoran-Rozenthal I. Zimlichman R. Ageno W. Agnelli G. Bova C. Garbelotto R. Ghirarduzzi A. Imberti D. Pesavento R. Porreca E. Visonà A. Flota Cervera L. Llamas Esperón G. Rodriguez-Gonzalez D. Solis Morales L. Boersma W. ten Cate H. Erdkamp F. Grifioen-Keijzer A. Marwijk Kooy M. Meijer K. Middeldorp S. Swart-Heikens J. Ten Wolde M. Westerweel P. Braithwaite I. Harper P. Merriman E. Ockelford P. Royle G. Smith M. Ghanima W. Sandset P.M. Abola M. Chęciński P. Grzelakowski P. Lewczuk J. Sobkowicz B. Tomkowski W. Abramov I. Chechulov P. Karpenko A. Katelnitskiy I. Kazakov A. Makarova O. Panchenko E. Sergeeva E. Subbotin Y. Suchkov I. Zeltser M. Adler D. Breedt J. Fourie N. Isaacs R. Jacobson B. Siebert H. van Zyl L. Choi J-H Kang S-M Kim K-H Kim H-S Kim D-I Min S-K Park K.H. García-Bragado Dalmau F. Gómez Cerezo J. Mirete JCF Riera A. Del Toro J. Eriksson H. Torstensson I. Banyai M. Baumgartner I. Mazzolai L. Periard D. Righini M. Staub D. Chiang C-E Chiu K-M Pai P-Y Angchaisuksiri P. Chansung K. Öngen G. Tuncay E. Alikhan R. Chetter I. Kesteven P. Nokes T. Bauer K. Comerota A. Elias D. Garcia D. Gibson K. Ginsberg D. Jenkins J. Kingsley E. Lambert R. Lyons R. Pullman J. Shah V. Smith S.W. Stein R. Tapson V. Walsh J. Wang T-F Do Loi D. Do Quang H. Pham N. The New England journal of medicine 376/13(2017-03-30), 1211-1222 376:13<1211-1222 2017 376 1 article serval SERVAL 700 1- Weitz J.I. aut SERVAL 700 1- Lensing AWA aut SERVAL 700 1- Prins M.H. aut SERVAL 700 1- Bauersachs R. aut SERVAL 700 1- Beyer-Westendorf J. aut SERVAL 700 1- Bounameaux H. aut SERVAL 700 1- Brighton T.A. aut SERVAL 700 1- Cohen A.T. aut SERVAL 700 1- Davidson B.L. aut SERVAL 700 1- Decousus H. aut SERVAL 700 1- Freitas MCS aut SERVAL 700 1- Holberg G. aut SERVAL 700 1- Kakkar A.K. aut SERVAL 700 1- Haskell L. aut SERVAL 700 1- van Bellen B. aut SERVAL 700 1- Pap A.F. aut SERVAL 700 1- Berkowitz S.D. aut SERVAL 700 1- Verhamme P. aut SERVAL 700 1- Wells P.S. aut SERVAL 700 1- Prandoni P. aut SERVAL 700 1- Bianchi A. SERVAL 700 1- Brighton T. SERVAL 700 1- Carroll P. SERVAL 700 1- Chong B. SERVAL 700 1- Chunilal S. SERVAL 700 1- Coughlin P. SERVAL 700 1- Curnow J. SERVAL 700 1- Jackson D. SERVAL 700 1- Tran H. SERVAL 700 1- Ward C. SERVAL 700 1- Brodmann M. SERVAL 700 1- Kyrle P. SERVAL 700 1- Marschang P. SERVAL 700 1- Petkov V. SERVAL 700 1- Hainaut P. SERVAL 700 1- Jordens P. SERVAL 700 1- Vandekerkhof J. SERVAL 700 1- Verhamme P. SERVAL 700 1- Wautrecht J-C SERVAL 700 1- Annichino-Bizzacchi J. SERVAL 700 1- van Bellen B. SERVAL 700 1- Correa J. SERVAL 700 1- Cukier A. SERVAL 700 1- Freire A. SERVAL 700 1- Pereira A. SERVAL 700 1- Porto C. SERVAL 700 1- Sacilotto R. SERVAL 700 1- Vasconcelos Costa A. SERVAL 700 1- Della Siega A. SERVAL 700 1- Dolan S. SERVAL 700 1- Le Gal G. SERVAL 700 1- Gross P. SERVAL 700 1- Kahn S. SERVAL 700 1- Kassis J. SERVAL 700 1- Kovacs M. SERVAL 700 1- Pesant Y. SERVAL 700 1- Ritchie B. SERVAL 700 1- Schulman S. SERVAL 700 1- Shivakumar S. SERVAL 700 1- Solymoss S. SERVAL 700 1- Chang S. SERVAL 700 1- Chen R. SERVAL 700 1- Chen Z. SERVAL 700 1- Chen H. SERVAL 700 1- Dai X. SERVAL 700 1- Fang B. SERVAL 700 1- Fu W. SERVAL 700 1- Gao X. SERVAL 700 1- Huang J. SERVAL 700 1- Lai Y. SERVAL 700 1- Li L. SERVAL 700 1- Li X. SERVAL 700 1- Li Y. SERVAL 700 1- Liu J. SERVAL 700 1- Liu S. SERVAL 700 1- Ma W. SERVAL 700 1- Ni S. SERVAL 700 1- Qin Z. SERVAL 700 1- Shi G. SERVAL 700 1- Tian H. SERVAL 700 1- Wang S. SERVAL 700 1- Wang L. SERVAL 700 1- Xiao W. SERVAL 700 1- Ying K. SERVAL 700 1- Yu G. SERVAL 700 1- Yuan Y. SERVAL 700 1- Zhang J. SERVAL 700 1- Zhang X. SERVAL 700 1- Zhang L. SERVAL 700 1- Zhu L. SERVAL 700 1- Chlumský J. SERVAL 700 1- Chochola J. SERVAL 700 1- Dunaj M. SERVAL 700 1- Kovarova K. SERVAL 700 1- Lang P. SERVAL 700 1- Matoška P. SERVAL 700 1- Podpera I. SERVAL 700 1- Spacek R. SERVAL 700 1- Stehlikova O. SERVAL 700 1- Brønnum-Schou J. SERVAL 700 1- Egstrup K. SERVAL 700 1- Gislason G. SERVAL 700 1- Jeppesen J. SERVAL 700 1- May O. SERVAL 700 1- Nielsen H. SERVAL 700 1- Wiggers H. SERVAL 700 1- Achkar A. SERVAL 700 1- Aquilanti S. SERVAL 700 1- Benhamou Y. SERVAL 700 1- Brisot D. SERVAL 700 1- Bura-Riviere A. SERVAL 700 1- Castella N. SERVAL 700 1- Elias A. SERVAL 700 1- Falvo N. SERVAL 700 1- Ferrari E. SERVAL 700 1- Lacroix P. SERVAL 700 1- Mahe I. SERVAL 700 1- Meneveau N. SERVAL 700 1- Messas E. SERVAL 700 1- Mismetti P. SERVAL 700 1- Montaclair K. SERVAL 700 1- Mottier D. SERVAL 700 1- Moumneh T. SERVAL 700 1- Paleiron N. SERVAL 700 1- Parent F. SERVAL 700 1- Pernod G. SERVAL 700 1- Sanchez O. SERVAL 700 1- Schmidt J. SERVAL 700 1- Simoneau G. SERVAL 700 1- Stephan D. SERVAL 700 1- Amann B. SERVAL 700 1- Bauersachs R. SERVAL 700 1- Beyer-Westendorf J. SERVAL 700 1- Blessing E. SERVAL 700 1- Czihal M. SERVAL 700 1- Espinola-Klein C. SERVAL 700 1- Kahrmann G. SERVAL 700 1- Licka M. SERVAL 700 1- Neumeister A. SERVAL 700 1- Schellong S. SERVAL 700 1- Boda Z. SERVAL 700 1- Farkas K. SERVAL 700 1- Gurzo M. SERVAL 700 1- Katona A. SERVAL 700 1- Riba M. SERVAL 700 1- Sipos G. SERVAL 700 1- Tóth K. SERVAL 700 1- Braester A. SERVAL 700 1- Elias M. SERVAL 700 1- Gafter-Gvili A. SERVAL 700 1- Gavish D. SERVAL 700 1- Hussein O. SERVAL 700 1- Lishner M. SERVAL 700 1- Schiff E. SERVAL 700 1- Spectre G. SERVAL 700 1- Tzoran-Rozenthal I. SERVAL 700 1- Zimlichman R. SERVAL 700 1- Ageno W. SERVAL 700 1- Agnelli G. SERVAL 700 1- Bova C. SERVAL 700 1- Garbelotto R. SERVAL 700 1- Ghirarduzzi A. SERVAL 700 1- Imberti D. SERVAL 700 1- Pesavento R. SERVAL 700 1- Porreca E. SERVAL 700 1- Visonà A. SERVAL 700 1- Flota Cervera L. SERVAL 700 1- Llamas Esperón G. SERVAL 700 1- Rodriguez-Gonzalez D. SERVAL 700 1- Solis Morales L. SERVAL 700 1- Boersma W. SERVAL 700 1- ten Cate H. SERVAL 700 1- Erdkamp F. SERVAL 700 1- Grifioen-Keijzer A. SERVAL 700 1- Marwijk Kooy M. SERVAL 700 1- Meijer K. SERVAL 700 1- Middeldorp S. SERVAL 700 1- Swart-Heikens J. SERVAL 700 1- Ten Wolde M. SERVAL 700 1- Westerweel P. SERVAL 700 1- Braithwaite I. SERVAL 700 1- Harper P. SERVAL 700 1- Merriman E. SERVAL 700 1- Ockelford P. SERVAL 700 1- Royle G. SERVAL 700 1- Smith M. SERVAL 700 1- Ghanima W. SERVAL 700 1- Sandset P.M. SERVAL 700 1- Abola M. SERVAL 700 1- Chęciński P. SERVAL 700 1- Grzelakowski P. SERVAL 700 1- Lewczuk J. SERVAL 700 1- Sobkowicz B. SERVAL 700 1- Tomkowski W. SERVAL 700 1- Abramov I. SERVAL 700 1- Chechulov P. SERVAL 700 1- Karpenko A. SERVAL 700 1- Katelnitskiy I. SERVAL 700 1- Kazakov A. SERVAL 700 1- Makarova O. SERVAL 700 1- Panchenko E. SERVAL 700 1- Sergeeva E. SERVAL 700 1- Subbotin Y. SERVAL 700 1- Suchkov I. SERVAL 700 1- Zeltser M. SERVAL 700 1- Adler D. SERVAL 700 1- Breedt J. SERVAL 700 1- Fourie N. SERVAL 700 1- Isaacs R. SERVAL 700 1- Jacobson B. SERVAL 700 1- Siebert H. SERVAL 700 1- van Zyl L. SERVAL 700 1- Choi J-H SERVAL 700 1- Kang S-M SERVAL 700 1- Kim K-H SERVAL 700 1- Kim H-S SERVAL 700 1- Kim D-I SERVAL 700 1- Min S-K SERVAL 700 1- Park K.H. SERVAL 700 1- García-Bragado Dalmau F. SERVAL 700 1- Gómez Cerezo J. SERVAL 700 1- Mirete JCF SERVAL 700 1- Riera A. SERVAL 700 1- Del Toro J. SERVAL 700 1- Eriksson H. SERVAL 700 1- Torstensson I. SERVAL 700 1- Banyai M. SERVAL 700 1- Baumgartner I. SERVAL 700 1- Mazzolai L. SERVAL 700 1- Periard D. SERVAL 700 1- Righini M. SERVAL 700 1- Staub D. SERVAL 700 1- Chiang C-E SERVAL 700 1- Chiu K-M SERVAL 700 1- Pai P-Y SERVAL 700 1- Angchaisuksiri P. SERVAL 700 1- Chansung K. SERVAL 700 1- Öngen G. SERVAL 700 1- Tuncay E. SERVAL 700 1- Alikhan R. SERVAL 700 1- Chetter I. SERVAL 700 1- Kesteven P. SERVAL 700 1- Nokes T. SERVAL 700 1- Bauer K. SERVAL 700 1- Comerota A. SERVAL 700 1- Elias D. SERVAL 700 1- Garcia D. SERVAL 700 1- Gibson K. SERVAL 700 1- Ginsberg D. SERVAL 700 1- Jenkins J. SERVAL 700 1- Kingsley E. SERVAL 700 1- Lambert R. SERVAL 700 1- Lyons R. SERVAL 700 1- Pullman J. SERVAL 700 1- Shah V. SERVAL 700 1- Smith S.W. SERVAL 700 1- Stein R. SERVAL 700 1- Tapson V. SERVAL 700 1- Walsh J. SERVAL 700 1- Wang T-F SERVAL 700 1- Do Loi D. SERVAL 700 1- Do Quang H. SERVAL 700 1- Pham N. SERVAL 773 0- The New England journal of medicine 376/13(2017-03-30), 1211-1222 376:13<1211-1222 2017 376 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article