caa a22 4500 530185156 CHVBK 20190303133649.0 cr unu---uuuuu 181026s2019 xx s 000 0 eng 10.1016/j.archger.2018.10.003 doi (SERVAL)BIB_923BD56F9AD2 30336372 pmid 000450882400004 isiid Childhood adversity: A gateway to multimorbidity in older age? [Elektronische Daten] [Y. Henchoz, L. Seematter-Bagnoud, D. Nanchen, C. Büla, A. von Gunten, J.F. Démonet, B. Santos-Eggimann] Multimorbidity, or co-occurrence of several chronic diseases, has major consequences in terms of function, quality of life and mortality. Recent advances suggest that the aetiology of multimorbidity includes a life-long process. The purpose of this study was to determine the association between childhood adversity and multimorbidity in community-dwelling older adults, and to investigate variation in participants born immediately before, during and at the end of the Second World War. Participants were 4731 community-dwelling older adults who enrolled in the Lausanne cohort 65+ study (Switzerland) at age 65-70 years in 2004/2009/2014. A baseline questionnaire provided several indicators of childhood adversity including premature birth, food restrictions, child labour, family economic environment, serious illness/accident, and stressful life events. Multimorbidity at age 67-72 years was defined as ≥2 active chronic diseases at the 2-year follow-up questionnaire. All childhood adversity indicators except premature birth were significantly associated with multimorbidity. Odds ratio (OR) ranged from 1.23 (P = 0.034) for poor family economic environment to 1.74 (P &lt; 0.001) for stressful life events. In a multivariable model adjusted for socioeconomic status, health behaviours and stressful life events in adulthood (&gt;16 years), a history of serious illness/accident (OR = 1.45; P &lt; 0.001) and stressful life events (OR = 1.42; P = 0.001) in childhood remained significantly associated with multimorbidity. Comparisons between cohorts indicated substantial variations in the prevalence of childhood adversity indicators but similar associations with multimorbidity. There was an independent association between childhood adversity and multimorbidity after age 65. This study encourages a comprehensive life-course perspective to better understand and potentially prevent multimorbidity. Henchoz Y. aut Seematter-Bagnoud L. aut Nanchen D. aut Büla C. aut von Gunten A. aut Démonet J.F. aut Santos-Eggimann B. aut Archives of gerontology and geriatrics 80(2019), 31-37 80<31-37 2019 80 1 article serval SERVAL 700 1- Henchoz Y. aut SERVAL 700 1- Seematter-Bagnoud L. aut SERVAL 700 1- Nanchen D. aut SERVAL 700 1- Büla C. aut SERVAL 700 1- von Gunten A. aut SERVAL 700 1- Démonet J.F. aut SERVAL 700 1- Santos-Eggimann B. aut SERVAL 773 0- Archives of gerontology and geriatrics 80(2019), 31-37 80<31-37 2019 80 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article