naa a22 4500 530185318 CHVBK 20181026074444.0 cr unu---uuuuu 181026e201710 xx s 000 0 eng 10.1002/rth2.12036 doi (SERVAL)BIB_BB8DC8C1A571 30046687 pmid Clinical outcomes during anticoagulant therapy in fragile patients with venous thromboembolism [Elektronische Daten] [F. Moustafa, M. Giorgi Pierfranceschi, P. Di Micco, E. Bucherini, A. Lorenzo, A. Villalobos, J.A. Nieto, B. Valero, Á.L. Sampériz, M. Monreal, H. Decousus, P. Prandoni, B. Brenner, R. Barba, L. Bertoletti, I. Tzoran, A. Reis, M. Bosevski, H. Bounameaux, R. Malý, P. Wells, M. Papadakis, M.D. Adarraga, P. Agudo, M.A. Aibar, M. Alfonso, J.I. Arcelus, A. Ballaz, R. Barba, M. Barrón, B. Barrón-Andrés, J. Bascuñana, A. Blanco-Molina, I. Cañas, I. Casado, N. Chic, R. Del Pozo, J. Del Toro, M.C. Díaz-Pedroche, J.A. Díaz-Peromingo, C. Falgá, C. Fernández-Aracil, C. Fernández-Capitán, M.A. Fidalgo, C. Font, L. Font, P. Gallego, M.A. García, F. García-Bragado, O. Gavín, C. Gómez, V. Gómez, J. González, E. Grau, A. Grimón, R. Guijarro, L. Guirado, J. Gutiérrez, G. Hernández-Comes, L. Hernández-Blasco, L. Jara-Palomares, M.J. Jaras, D. Jiménez, J. Jiménez, M.D. Joya, P. Llamas, J.L. Lobo, P. López, L. López-Jiménez, R. López-Reyes, J.B. López-Sáez, M.A. Lorente, M. Lumbierres, J.M. Luque, P.J. Marchena, F. Martín-Martos, M. Mellado, S. Nieto, A. Núñez, M.J. Núñez, S. Otalora, R. Otero, J.M. Pedrajas, G. Pérez, C. Pérez-Ductor, M.L. Peris, I. Pons, J.A. Porras, O. Reig, A. Riera-Mestre, D. Riesco, A. Rivas, M. Rodríguez, M.A. Rodríguez-Dávila, V. Rosa, E. Rosillo-Hernández, P. Ruiz-Artacho, N. Ruiz-Giménez, J.C. Sahuquillo, M.C. Sala-Sainz, R. Sánchez-Martínez, O. Sanz, S. Soler, B. Sopeña, J.M. Suriñach, C. Tolosa, M.I. Torres, J. Troya, J. Trujillo-Santos, F. Uresandi, E. Usandizaga, R. Valle, J. Vela, L. Vela, M.P. Vicente, B. Xifre, T. Vanassche, P. Verhamme, H. Yoo, P. Wells, J. Hirmerova, R. Malý, P. Dulíček, E. Salgado, L. Bertoletti, A. Bura-Riviere, D. Farge-Bancel, A. Hij, I. Mahé, A. Merah, A. Braester, B. Brenner, I. Tzoran, G. Antonucci, G. Barillari, F. Bilora, C. Bortoluzzi, B. Brandolin, C. Cattabiani, M. Ciammaichella, N. Dell'Elce, F. Dentali, R. Duce, E. Grandone, E. Imbalzano, G. Lessiani, R. Maida, D. Mastroiacovo, F. Pace, R. Parisi, M. Pellegrinet, R. Pesavento, M. Pinelli, R. Poggio, P. Prandoni, R. Quintavalla, A. Rocci, E. Tiraferri, D. Tonello, A. Tufano, A. Visonà, V. Gibietis, A. Skride, B. Vitola, M. Bosevski, M. Zdraveska, H. Bounameaux, L. Mazzolai] Subgroup analyses from randomized trials suggested favorable results for the direct oral anticoagulants in fragile patients with venous thromboembolism (VTE). The frequency and natural history of fragile patients with VTE have not been studied yet. To compare the clinical characteristics, treatment and outcomes during the first 3months of anticoagulation in fragile vs non-fragile patients with VTE. Retrospective study using consecutive patients enrolled in the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry. Fragile patients were defined as those having age ≥75years, creatinine clearance (CrCl) levels ≤50mL/min, and/or body weight ≤50kg. From January 2013 to October 2016, 15079 patients were recruited. Of these, 6260 (42%) were fragile: 37% were aged ≥75years, 20% had CrCl levels ≤50mL/min, and 3.6% weighed ≤50kg. During the first 3months of anticoagulant therapy, fragile patients had a lower risk of VTE recurrences (0.78% vs 1.4%; adjusted odds ratio [OR]: 0.52; 95% confidence intervals [CI]: 0.37-0.74) and a higher risk of major bleeding (2.6% vs 1.4%; adjusted OR: 1.41; 95% CI: 1.10-1.80), gastrointestinal bleeding (0.86% vs 0.35%; adjusted OR: 1.84; 95% CI: 1.16-2.92), haematoma (0.51% vs 0.07%; adjusted OR: 5.05; 95% CI: 2.05-12.4), all-cause death (9.2% vs 3.5%; adjusted OR: 2.02; 95% CI: 1.75-2.33), or fatal PE (0.85% vs 0.35%; adjusted OR: 1.77; 95% CI: 1.10-2.85) than the non-fragile. In real life, 42% of VTE patients were fragile. During anticoagulation, they had fewer VTE recurrences and more major bleeding events than the non-fragile. Moustafa F. aut Giorgi Pierfranceschi M. aut Di Micco P. aut Bucherini E. aut Lorenzo A. aut Villalobos A. aut Nieto J.A. aut Valero B. aut Sampériz Á.L. aut Monreal M. aut Decousus H. Prandoni P. Brenner B. Barba R. Bertoletti L. Tzoran I. Reis A. Bosevski M. Bounameaux H. Malý R. Wells P. Papadakis M. Adarraga M.D. Agudo P. Aibar M.A. Alfonso M. Arcelus J.I. Ballaz A. Barrón M. Barrón-Andrés B. Bascuñana J. Blanco-Molina A. Cañas I. Casado I. Chic N. Del Pozo R. Del Toro J. Díaz-Pedroche M.C. Díaz-Peromingo J.A. Falgá C. Fernández-Aracil C. Fernández-Capitán C. Fidalgo M.A. Font C. Font L. Gallego P. García M.A. García-Bragado F. Gavín O. Gómez C. Gómez V. González J. Grau E. Grimón A. Guijarro R. Guirado L. Gutiérrez J. Hernández-Comes G. Hernández-Blasco L. Jara-Palomares L. Jaras M.J. Jiménez D. Jiménez J. Joya M.D. Llamas P. Lobo J.L. López P. López-Jiménez L. López-Reyes R. López-Sáez J.B. Lorente M.A. Lumbierres M. Luque J.M. Marchena P.J. Martín-Martos F. Mellado M. Nieto S. Núñez A. Núñez M.J. Otalora S. Otero R. Pedrajas J.M. Pérez G. Pérez-Ductor C. Peris M.L. Pons I. Porras J.A. Reig O. Riera-Mestre A. Riesco D. Rivas A. Rodríguez M. Rodríguez-Dávila M.A. Rosa V. Rosillo-Hernández E. Ruiz-Artacho P. Ruiz-Giménez N. Sahuquillo J.C. Sala-Sainz M.C. Sánchez-Martínez R. Sanz O. Soler S. Sopeña B. Suriñach J.M. Tolosa C. Torres M.I. Troya J. Trujillo-Santos J. Uresandi F. Usandizaga E. Valle R. Vela J. Vela L. Vicente M.P. Xifre B. Vanassche T. Verhamme P. Yoo H. Hirmerova J. Dulíček P. Salgado E. Bura-Riviere A. Farge-Bancel D. Hij A. Mahé I. Merah A. Braester A. Antonucci G. Barillari G. Bilora F. Bortoluzzi C. Brandolin B. Cattabiani C. Ciammaichella M. Dell'Elce N. Dentali F. Duce R. Grandone E. Imbalzano E. Lessiani G. Maida R. Mastroiacovo D. Pace F. Parisi R. Pellegrinet M. Pesavento R. Pinelli M. Poggio R. Quintavalla R. Rocci A. Tiraferri E. Tonello D. Tufano A. Visonà A. Gibietis V. Skride A. Vitola B. Zdraveska M. Mazzolai L. Research and practice in thrombosis and haemostasis 1/2(2017-10), 172-179 1:2<172-179 2017 1 1 article serval SERVAL 700 1- Moustafa F. aut SERVAL 700 1- Giorgi Pierfranceschi M. aut SERVAL 700 1- Di Micco P. aut SERVAL 700 1- Bucherini E. aut SERVAL 700 1- Lorenzo A. aut SERVAL 700 1- Villalobos A. aut SERVAL 700 1- Nieto J.A. aut SERVAL 700 1- Valero B. aut SERVAL 700 1- Sampériz Á.L. aut SERVAL 700 1- Monreal M. aut SERVAL 700 1- Decousus H. SERVAL 700 1- Prandoni P. SERVAL 700 1- Brenner B. SERVAL 700 1- Barba R. SERVAL 700 1- Bertoletti L. SERVAL 700 1- Tzoran I. SERVAL 700 1- Reis A. SERVAL 700 1- Bosevski M. SERVAL 700 1- Bounameaux H. SERVAL 700 1- Malý R. SERVAL 700 1- Wells P. SERVAL 700 1- Papadakis M. SERVAL 700 1- Adarraga M.D. SERVAL 700 1- Agudo P. SERVAL 700 1- Aibar M.A. SERVAL 700 1- Alfonso M. SERVAL 700 1- Arcelus J.I. SERVAL 700 1- Ballaz A. SERVAL 700 1- Barrón M. SERVAL 700 1- Barrón-Andrés B. SERVAL 700 1- Bascuñana J. SERVAL 700 1- Blanco-Molina A. SERVAL 700 1- Cañas I. SERVAL 700 1- Casado I. SERVAL 700 1- Chic N. SERVAL 700 1- Del Pozo R. SERVAL 700 1- Del Toro J. SERVAL 700 1- Díaz-Pedroche M.C. SERVAL 700 1- Díaz-Peromingo J.A. SERVAL 700 1- Falgá C. SERVAL 700 1- Fernández-Aracil C. SERVAL 700 1- Fernández-Capitán C. SERVAL 700 1- Fidalgo M.A. SERVAL 700 1- Font C. SERVAL 700 1- Font L. SERVAL 700 1- Gallego P. SERVAL 700 1- García M.A. SERVAL 700 1- García-Bragado F. SERVAL 700 1- Gavín O. SERVAL 700 1- Gómez C. SERVAL 700 1- Gómez V. SERVAL 700 1- González J. SERVAL 700 1- Grau E. SERVAL 700 1- Grimón A. SERVAL 700 1- Guijarro R. SERVAL 700 1- Guirado L. SERVAL 700 1- Gutiérrez J. SERVAL 700 1- Hernández-Comes G. SERVAL 700 1- Hernández-Blasco L. SERVAL 700 1- Jara-Palomares L. SERVAL 700 1- Jaras M.J. SERVAL 700 1- Jiménez D. SERVAL 700 1- Jiménez J. SERVAL 700 1- Joya M.D. SERVAL 700 1- Llamas P. SERVAL 700 1- Lobo J.L. SERVAL 700 1- López P. SERVAL 700 1- López-Jiménez L. SERVAL 700 1- López-Reyes R. SERVAL 700 1- López-Sáez J.B. SERVAL 700 1- Lorente M.A. SERVAL 700 1- Lumbierres M. SERVAL 700 1- Luque J.M. SERVAL 700 1- Marchena P.J. SERVAL 700 1- Martín-Martos F. SERVAL 700 1- Mellado M. SERVAL 700 1- Nieto S. SERVAL 700 1- Núñez A. SERVAL 700 1- Núñez M.J. SERVAL 700 1- Otalora S. SERVAL 700 1- Otero R. SERVAL 700 1- Pedrajas J.M. SERVAL 700 1- Pérez G. SERVAL 700 1- Pérez-Ductor C. SERVAL 700 1- Peris M.L. SERVAL 700 1- Pons I. SERVAL 700 1- Porras J.A. SERVAL 700 1- Reig O. SERVAL 700 1- Riera-Mestre A. SERVAL 700 1- Riesco D. SERVAL 700 1- Rivas A. SERVAL 700 1- Rodríguez M. SERVAL 700 1- Rodríguez-Dávila M.A. SERVAL 700 1- Rosa V. SERVAL 700 1- Rosillo-Hernández E. SERVAL 700 1- Ruiz-Artacho P. SERVAL 700 1- Ruiz-Giménez N. SERVAL 700 1- Sahuquillo J.C. SERVAL 700 1- Sala-Sainz M.C. SERVAL 700 1- Sánchez-Martínez R. SERVAL 700 1- Sanz O. SERVAL 700 1- Soler S. SERVAL 700 1- Sopeña B. SERVAL 700 1- Suriñach J.M. SERVAL 700 1- Tolosa C. SERVAL 700 1- Torres M.I. SERVAL 700 1- Troya J. SERVAL 700 1- Trujillo-Santos J. SERVAL 700 1- Uresandi F. SERVAL 700 1- Usandizaga E. SERVAL 700 1- Valle R. SERVAL 700 1- Vela J. SERVAL 700 1- Vela L. SERVAL 700 1- Vicente M.P. SERVAL 700 1- Xifre B. SERVAL 700 1- Vanassche T. SERVAL 700 1- Verhamme P. SERVAL 700 1- Yoo H. SERVAL 700 1- Hirmerova J. SERVAL 700 1- Dulíček P. SERVAL 700 1- Salgado E. SERVAL 700 1- Bura-Riviere A. SERVAL 700 1- Farge-Bancel D. SERVAL 700 1- Hij A. SERVAL 700 1- Mahé I. SERVAL 700 1- Merah A. SERVAL 700 1- Braester A. SERVAL 700 1- Antonucci G. SERVAL 700 1- Barillari G. SERVAL 700 1- Bilora F. SERVAL 700 1- Bortoluzzi C. SERVAL 700 1- Brandolin B. SERVAL 700 1- Cattabiani C. SERVAL 700 1- Ciammaichella M. SERVAL 700 1- Dell'Elce N. SERVAL 700 1- Dentali F. SERVAL 700 1- Duce R. SERVAL 700 1- Grandone E. SERVAL 700 1- Imbalzano E. SERVAL 700 1- Lessiani G. SERVAL 700 1- Maida R. SERVAL 700 1- Mastroiacovo D. SERVAL 700 1- Pace F. SERVAL 700 1- Parisi R. SERVAL 700 1- Pellegrinet M. SERVAL 700 1- Pesavento R. SERVAL 700 1- Pinelli M. SERVAL 700 1- Poggio R. SERVAL 700 1- Quintavalla R. SERVAL 700 1- Rocci A. SERVAL 700 1- Tiraferri E. SERVAL 700 1- Tonello D. SERVAL 700 1- Tufano A. SERVAL 700 1- Visonà A. SERVAL 700 1- Gibietis V. SERVAL 700 1- Skride A. SERVAL 700 1- Vitola B. SERVAL 700 1- Zdraveska M. SERVAL 700 1- Mazzolai L. SERVAL 773 0- Research and practice in thrombosis and haemostasis 1/2(2017-10), 172-179 1:2<172-179 2017 1 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article