naa a22 4500 530185334 CHVBK 20181026074444.0 cr unu---uuuuu 181026e201804 xx s 000 0 eng 10.1007/s11239-018-1610-9 doi (SERVAL)BIB_C3E0B110BAD4 29383557 pmid 000427399400005 isiid Anemia and bleeding in patients receiving anticoagulant therapy for venous thromboembolism [Elektronische Daten] [A. Kuperman, R. López-Reyes, L.J. Bosco, A. Lorenzo, B. José, D. Farge Bancel, M. Alfonso, M. Lumbierres, G. Stemer, M. Monreal Bosch, A. Braester, M.D. Adarraga, M.A. Aibar, M. Alfonso, J.I. Arcelus, A. Ballaz, P. Baños, R. Barba, M. Barrón, J. Bascuñana, E. Bautista, A. Blanco-Molina, A.M. Camón, A.J. Cruz, R. Del Pozo, J. Del Toro, M.C. Díaz-Pedroche, J.A. Díaz-Peromingo, J.C. Escribano, C. Falgá, C. Fernández-Aracil, C. Fernández-Capitán, M.A. Fidalgo, C. Font, L. Font, M.A. García, F. García-Bragado, M. García-Morillo, A. García-Raso, O. Gavín, I. Gaya-Manso, C. Gómez, V. Gómez, J. González, E. Grau, A. Grimón, R. Guijarro, J. Gutiérrez, G. Hernández-Comes, L. Hernández-Blasco, E. Hernando, L. Jara-Palomares, M.J. Jaras, D. Jiménez, M.D. Joya, J. Lima, P. Llamas, J.L. Lobo, L. López-Jiménez, R. López-Reyes, J.B. López-Sáez, M.A. Lorente, A. Lorenzo, M. Loring, M. Lumbierres, O. Madridano, A. Maestre, P.J. Marchena, M. Martín, F. Martín-Martos, M. Martín-Romero, M. Monreal, M.V. Morales, J.A. Nieto, S. Nieto, A. Núñez, M.J. Núñez, M. Odriozola, M.C. Olivares, S. Otalora, R. Otero, J.M. Pedrajas, G. Pellejero, C. Pérez-Ductor, G. Pérez-Rus, M.L. Peris, I. Pons, J.A. Porras, A. Riera-Mestre, A. Rivas, M.A. Rodríguez-Dávila, V. Rosa, C.M. Rubio, P. Ruiz-Artacho, J.C. Sahuquillo, A. Sala-Sainz, A. Sampériz, R. Sánchez-Martínez, S. Soler, M.J. Soto, J.M. Suriñach, C. Tolosa, M.I. Torres, J. Trujillo-Santos, F. Uresandi, E. Usandizaga, B. Valero, R. Valle, J. Vela, G. Vidal, A. Villalobos, T. Vanassche, C. Vandenbriele, P. Verhamme, HHB Yoo, P. Wells, J. Hirmerova, R. Malý, G. Del Pozo, E. Salgado, G.T. Sánchez, I. Benzidia, L. Bertoletti, A. Bura-Riviere, N. Falvo, D. Farge-Bancel, A. Hij, A. Merah, I. Mahé, F. Moustafa, I. Quere, A. Braester, B. Brenner, M. Ellis, I. Tzoran, G. Antonucci, G. Barillari, F. Bilora, C. Bortoluzzi, E. Bucherini, C. Cattabiani, M. Celeste, M. Ciammaichella, N. Dell'Elce, F. Dentali, P. Di Micco, R. Duce, M. Giorgi-Pierfranceschi, E. Grandone, E. Imbalzano, G. Lessiani, R. Maida, D. Mastroiacovo, F. Pace, R. Pesavento, R. Poggio, P. Prandoni, R. Quintavalla, A. Rocci, C. Siniscalchi, E. Tiraferri, D. Tonello, A. Visonà, B. Zalunardo, D. Kigitovica, K. Sablinskis, A. Skride, H. Bounameaux, L. Calanca, O. Hugli, L. Mazzolai] In patients receiving anticoagulant therapy for venous thromboembolism (VTE), the important issue of anemia influence on the risk of bleeding has not been consistently studied. We used the large registry data RIETE (Registro Informatizado Enfermedad Tromboembólica) to compare the rate of major bleeding in patients receiving anticoagulant therapy for VTE according to the presence or absence of anemia at baseline. Patients with or without cancer were separately studied. Until August 2016, 63492 patients had been enrolled. Of these, 21652 (34%) had anemia and 14312 (23%) had cancer. Anemia was found in 57% of the patients with cancer and in 28% without (odds ratio 3.46; 95% CI 3.33-3.60). During the course of anticoagulant therapy, 680 patients with cancer had a major bleeding event (gastrointestinal tract 43%, intracranial 14%, hematoma 12%). Cancer patients with anemia had a higher rate of major bleeding (rate ratio [RR]: 2.52; 95% CI 2.14-2.97) and fatal bleeding (RR 2.73; 95% CI 1.95-3.86) than those without anemia. During the course of anticoagulation, 1133 patients without cancer had major bleeding (gastrointestinal tract 32%, hematoma 24%, intracranial 21%). Patients with anemia had a higher rate of major bleeding (RR 2.84; 95% CI 2.52-2.39) and fatal bleeding (RR 2.76; 95% CI 2.07-3.67) than those without. On a multivariable analysis, anemia independently predicted the risk for major bleeding in patients with and without cancer (hazard ratios: 1.66; 95% CI 1.40-1.96 and 1.95; 95% CI 1.72-2.20, respectively). During anticoagulation for VTE, both cancer- and non-cancer anemic patients had a higher risk for major bleeding than those without anemia. In anemic patients (with or without cancer), the rate of major bleeding during the course of anticoagulant therapy exceeded the rate of VTE recurrences. In patients without anemia the rate of major bleeding was lower than the rate of VTE recurrences. Kuperman A. aut López-Reyes R. aut Bosco L.J. aut Lorenzo A. aut José B. aut Farge Bancel D. aut Alfonso M. aut Lumbierres M. aut Stemer G. aut Monreal Bosch M. aut Braester A. aut Adarraga M.D. Aibar M.A. Alfonso M. Arcelus J.I. Ballaz A. Baños P. Barba R. Barrón M. Bascuñana J. Bautista E. Blanco-Molina A. Camón A.M. Cruz A.J. Del Pozo R. Del Toro J. Díaz-Pedroche M.C. Díaz-Peromingo J.A. Escribano J.C. Falgá C. Fernández-Aracil C. Fernández-Capitán C. Fidalgo M.A. Font C. Font L. García M.A. García-Bragado F. García-Morillo M. García-Raso A. Gavín O. Gaya-Manso I. Gómez C. Gómez V. González J. Grau E. Grimón A. Guijarro R. Gutiérrez J. Hernández-Comes G. Hernández-Blasco L. Hernando E. Jara-Palomares L. Jaras M.J. Jiménez D. Joya M.D. Lima J. Llamas P. Lobo J.L. López-Jiménez L. López-Reyes R. López-Sáez J.B. Lorente M.A. Lorenzo A. Loring M. Lumbierres M. Madridano O. Maestre A. Marchena P.J. Martín M. Martín-Martos F. Martín-Romero M. Monreal M. Morales M.V. Nieto J.A. Nieto S. Núñez A. Núñez M.J. Odriozola M. Olivares M.C. Otalora S. Otero R. Pedrajas J.M. Pellejero G. Pérez-Ductor C. Pérez-Rus G. Peris M.L. Pons I. Porras J.A. Riera-Mestre A. Rivas A. Rodríguez-Dávila M.A. Rosa V. Rubio C.M. Ruiz-Artacho P. Sahuquillo J.C. Sala-Sainz A. Sampériz A. Sánchez-Martínez R. Soler S. Soto M.J. Suriñach J.M. Tolosa C. Torres M.I. Trujillo-Santos J. Uresandi F. Usandizaga E. Valero B. Valle R. Vela J. Vidal G. Villalobos A. Vanassche T. Vandenbriele C. Verhamme P. Yoo HHB Wells P. Hirmerova J. Malý R. Del Pozo G. Salgado E. Sánchez G.T. Benzidia I. Bertoletti L. Bura-Riviere A. Falvo N. Farge-Bancel D. Hij A. Merah A. Mahé I. Moustafa F. Quere I. Braester A. Brenner B. Ellis M. Tzoran I. Antonucci G. Barillari G. Bilora F. Bortoluzzi C. Bucherini E. Cattabiani C. Celeste M. Ciammaichella M. Dell'Elce N. Dentali F. Di Micco P. Duce R. Giorgi-Pierfranceschi M. Grandone E. Imbalzano E. Lessiani G. Maida R. Mastroiacovo D. Pace F. Pesavento R. Poggio R. Prandoni P. Quintavalla R. Rocci A. Siniscalchi C. Tiraferri E. Tonello D. Visonà A. Zalunardo B. Kigitovica D. Sablinskis K. Skride A. Bounameaux H. Calanca L. Hugli O. Mazzolai L. Journal of thrombosis and thrombolysis 45/3(2018-04), 360-368 45:3<360-368 2018 45 1 article serval SERVAL 700 1- Kuperman A. aut SERVAL 700 1- López-Reyes R. aut SERVAL 700 1- Bosco L.J. aut SERVAL 700 1- Lorenzo A. aut SERVAL 700 1- José B. aut SERVAL 700 1- Farge Bancel D. aut SERVAL 700 1- Alfonso M. aut SERVAL 700 1- Lumbierres M. aut SERVAL 700 1- Stemer G. aut SERVAL 700 1- Monreal Bosch M. aut SERVAL 700 1- Braester A. aut SERVAL 700 1- Adarraga M.D. SERVAL 700 1- Aibar M.A. SERVAL 700 1- Alfonso M. SERVAL 700 1- Arcelus J.I. SERVAL 700 1- Ballaz A. SERVAL 700 1- Baños P. SERVAL 700 1- Barba R. SERVAL 700 1- Barrón M. SERVAL 700 1- Bascuñana J. SERVAL 700 1- Bautista E. SERVAL 700 1- Blanco-Molina A. SERVAL 700 1- Camón A.M. SERVAL 700 1- Cruz A.J. SERVAL 700 1- Del Pozo R. SERVAL 700 1- Del Toro J. SERVAL 700 1- Díaz-Pedroche M.C. SERVAL 700 1- Díaz-Peromingo J.A. SERVAL 700 1- Escribano J.C. SERVAL 700 1- Falgá C. SERVAL 700 1- Fernández-Aracil C. SERVAL 700 1- Fernández-Capitán C. SERVAL 700 1- Fidalgo M.A. SERVAL 700 1- Font C. SERVAL 700 1- Font L. SERVAL 700 1- García M.A. SERVAL 700 1- García-Bragado F. SERVAL 700 1- García-Morillo M. SERVAL 700 1- García-Raso A. SERVAL 700 1- Gavín O. SERVAL 700 1- Gaya-Manso I. SERVAL 700 1- Gómez C. SERVAL 700 1- Gómez V. SERVAL 700 1- González J. SERVAL 700 1- Grau E. SERVAL 700 1- Grimón A. SERVAL 700 1- Guijarro R. SERVAL 700 1- Gutiérrez J. SERVAL 700 1- Hernández-Comes G. SERVAL 700 1- Hernández-Blasco L. SERVAL 700 1- Hernando E. SERVAL 700 1- Jara-Palomares L. SERVAL 700 1- Jaras M.J. SERVAL 700 1- Jiménez D. SERVAL 700 1- Joya M.D. SERVAL 700 1- Lima J. SERVAL 700 1- Llamas P. SERVAL 700 1- Lobo J.L. SERVAL 700 1- López-Jiménez L. SERVAL 700 1- López-Reyes R. SERVAL 700 1- López-Sáez J.B. SERVAL 700 1- Lorente M.A. SERVAL 700 1- Lorenzo A. SERVAL 700 1- Loring M. SERVAL 700 1- Lumbierres M. SERVAL 700 1- Madridano O. SERVAL 700 1- Maestre A. SERVAL 700 1- Marchena P.J. SERVAL 700 1- Martín M. SERVAL 700 1- Martín-Martos F. SERVAL 700 1- Martín-Romero M. SERVAL 700 1- Monreal M. SERVAL 700 1- Morales M.V. SERVAL 700 1- Nieto J.A. SERVAL 700 1- Nieto S. SERVAL 700 1- Núñez A. SERVAL 700 1- Núñez M.J. SERVAL 700 1- Odriozola M. SERVAL 700 1- Olivares M.C. SERVAL 700 1- Otalora S. SERVAL 700 1- Otero R. SERVAL 700 1- Pedrajas J.M. SERVAL 700 1- Pellejero G. SERVAL 700 1- Pérez-Ductor C. SERVAL 700 1- Pérez-Rus G. SERVAL 700 1- Peris M.L. SERVAL 700 1- Pons I. SERVAL 700 1- Porras J.A. SERVAL 700 1- Riera-Mestre A. SERVAL 700 1- Rivas A. SERVAL 700 1- Rodríguez-Dávila M.A. SERVAL 700 1- Rosa V. SERVAL 700 1- Rubio C.M. SERVAL 700 1- Ruiz-Artacho P. SERVAL 700 1- Sahuquillo J.C. SERVAL 700 1- Sala-Sainz A. SERVAL 700 1- Sampériz A. SERVAL 700 1- Sánchez-Martínez R. SERVAL 700 1- Soler S. SERVAL 700 1- Soto M.J. SERVAL 700 1- Suriñach J.M. SERVAL 700 1- Tolosa C. SERVAL 700 1- Torres M.I. SERVAL 700 1- Trujillo-Santos J. SERVAL 700 1- Uresandi F. SERVAL 700 1- Usandizaga E. SERVAL 700 1- Valero B. SERVAL 700 1- Valle R. SERVAL 700 1- Vela J. SERVAL 700 1- Vidal G. SERVAL 700 1- Villalobos A. SERVAL 700 1- Vanassche T. SERVAL 700 1- Vandenbriele C. SERVAL 700 1- Verhamme P. SERVAL 700 1- Yoo HHB SERVAL 700 1- Wells P. SERVAL 700 1- Hirmerova J. SERVAL 700 1- Malý R. SERVAL 700 1- Del Pozo G. SERVAL 700 1- Salgado E. SERVAL 700 1- Sánchez G.T. SERVAL 700 1- Benzidia I. SERVAL 700 1- Bertoletti L. SERVAL 700 1- Bura-Riviere A. SERVAL 700 1- Falvo N. SERVAL 700 1- Farge-Bancel D. SERVAL 700 1- Hij A. SERVAL 700 1- Merah A. SERVAL 700 1- Mahé I. SERVAL 700 1- Moustafa F. SERVAL 700 1- Quere I. SERVAL 700 1- Braester A. SERVAL 700 1- Brenner B. SERVAL 700 1- Ellis M. SERVAL 700 1- Tzoran I. SERVAL 700 1- Antonucci G. SERVAL 700 1- Barillari G. SERVAL 700 1- Bilora F. SERVAL 700 1- Bortoluzzi C. SERVAL 700 1- Bucherini E. SERVAL 700 1- Cattabiani C. SERVAL 700 1- Celeste M. SERVAL 700 1- Ciammaichella M. SERVAL 700 1- Dell'Elce N. SERVAL 700 1- Dentali F. SERVAL 700 1- Di Micco P. SERVAL 700 1- Duce R. SERVAL 700 1- Giorgi-Pierfranceschi M. SERVAL 700 1- Grandone E. SERVAL 700 1- Imbalzano E. SERVAL 700 1- Lessiani G. SERVAL 700 1- Maida R. SERVAL 700 1- Mastroiacovo D. SERVAL 700 1- Pace F. SERVAL 700 1- Pesavento R. SERVAL 700 1- Poggio R. SERVAL 700 1- Prandoni P. SERVAL 700 1- Quintavalla R. SERVAL 700 1- Rocci A. SERVAL 700 1- Siniscalchi C. SERVAL 700 1- Tiraferri E. SERVAL 700 1- Tonello D. SERVAL 700 1- Visonà A. SERVAL 700 1- Zalunardo B. SERVAL 700 1- Kigitovica D. SERVAL 700 1- Sablinskis K. SERVAL 700 1- Skride A. SERVAL 700 1- Bounameaux H. SERVAL 700 1- Calanca L. SERVAL 700 1- Hugli O. SERVAL 700 1- Mazzolai L. SERVAL 773 0- Journal of thrombosis and thrombolysis 45/3(2018-04), 360-368 45:3<360-368 2018 45 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article