naa a22 4500 530185482 CHVBK 20181026074445.0 cr unu---uuuuu 181026e201704 xx s 000 0 eng 10.1016/j.amjmed.2016.11.016 doi (SERVAL)BIB_37674A254CDD 27986523 pmid 000400462300040 isiid Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation [Elektronische Daten] [I. Tzoran, M. Papadakis, B. Brenner, Á. Fidalgo, A. Rivas, P.S. Wells, O. Gavín, M.D. Adarraga, F. Moustafa, M. Monreal, H. Decousus, P. Prandoni, B. Brenner, R. Barba, P. Di Micco, L. Bertoletti, I. Tzoran, A. Reis, M. Bosevski, H. Bounameaux, R. Malý, P. Wells, M. Papadakis, M.D. Adarraga, M.A. Aibar, M. Alfonso, J.I. Arcelus, R. Barba, M. Barrón, B. Barrón-Andrés, J. Bascuñana, A. Blanco-Molina, T. Bueso, G. Cañada, I. Cañas, N. Chic, R. Del Pozo, J. Del Toro, M.C. Díaz-Pedroche, J.A. Díaz-Peromingo, C. Falgá, C. Fernández-Capitán, M.A. Fidalgo, C. Font, L. Font, P. Gallego, A. García, M.A. García, F. García-Bragado, P. García-Brotons, O. Gavín, C. Gómez, V. Gómez, J. González, D. González-Marcano, E. Grau, A. Grimón, R. Guijarro, J. Gutiérrez, G. Hernández-Comes, L. Hernández-Blasco, M.J. Hermosa-Los Arcos, L. Jara-Palomares, M.J. Jaras, D. Jiménez, M.D. Joya, P. Llamas, R. Lecumberri, J.L. Lobo, P. López, L. López-Jiménez, R. López-Reyes, J.B. López-Sáez, M.A. Lorente, A. Lorenzo, A. Maestre, P.J. Marchena, F. Martín-Martos, M. Monreal, J.A. Nieto, S. Nieto, A. Núñez, M.J. Núñez, M. Odriozola, R. Otero, J.M. Pedrajas, G. Pérez, C. Pérez-Ductor, M.L. Peris, J.A. Porras, O. Reig, A. Riera-Mestre, D. Riesco, A. Rivas, C. Rodríguez, M.A. Rodríguez-Dávila, V. Rosa, N. Ruiz-Giménez, J.C. Sahuquillo, M.C. Sala-Sainz, A. Sampériz, R. Sánchez-Martínez, R. Sánchez Simón-Talero, O. Sanz, S. Soler, J.M. Suriñach, M.I. Torres, J. Trujillo-Santos, F. Uresandi, B. Valero, R. Valle, J. Vela, M.P. Vicente, A. Villalobos, T. Vanassche, P. Verhamme, P. Wells, J. Hirmerova, R. Malý, T. Tomko, G. Del Pozo, E. Salgado, G.T. Sánchez, L. Bertoletti, A. Bura-Riviere, I. Mahé, A. Merah, F. Moustafa, M. Papadakis, A. Braester, B. Brenner, I. Tzoran, G. Antonucci, G. Barillari, F. Bilora, C. Bortoluzzi, C. Cattabiani, M. Ciammaichella, J. Di Biase, P. Di Micco, R. Duce, P. Ferrazzi, M. Giorgi-Pierfranceschi, E. Grandone, E. Imbalzano, C. Lodigiani, R. Maida, D. Mastroiacovo, F. Pace, R. Pesavento, M. Pinelli, R. Poggio, P. Prandoni, L. Rota, E. Tiraferri, D. Tonello, A. Tufano, A. Visonà, B. Zalunardo, V. Gibietis, A. Skride, B. Vitola, P. Monteiro, J.L. Ribeiro, M.S. Sousa, M. Bosevski, M. Zdraveska, H. Bounameaux, L. Calanca, A. Erdmann, L. Mazzolai] Individuals with factor V Leiden or prothrombin G20210A mutations are at a higher risk to develop venous thromboembolism. However, the influence of these polymorphisms on patient outcome during anticoagulant therapy has not been consistently explored. We used the Registro Informatizado de Enfermedad TromboEmbólica database to compare rates of venous thromboembolism recurrence and bleeding events occurring during the anticoagulation course in factor V Leiden carriers, prothrombin mutation carriers, and noncarriers. Between March 2001 and December 2015, 10,139 patients underwent thrombophilia testing. Of these, 1384 were factor V Leiden carriers, 1115 were prothrombin mutation carriers, and 7640 were noncarriers. During the anticoagulation course, 160 patients developed recurrent deep vein thrombosis and 94 patients developed pulmonary embolism (16 died); 154 patients had major bleeding (10 died), and 291 patients had nonmajor bleeding. On multivariable analysis, factor V Leiden carriers had a similar rate of venous thromboembolism recurrence (adjusted hazard ratio [HR], 1.16; 95% confidence interval [CI], 0.82-1.64), half the rate of major bleeding (adjusted HR, 0.50; 95% CI, 0.25-0.99) and a nonsignificantly lower rate of nonmajor bleeding (adjusted HR, 0.66; 95% CI, 0.43-1.01) than noncarriers. Prothrombin mutation carriers and noncarriers had a comparable rate of venous thromboembolism recurrence (adjusted HR, 1.00; 95% CI, 0.68-1.48), major bleeding (adjusted HR, 0.75; 95% CI, 0.42-1.34), and nonmajor bleeding events (adjusted HR, 1.10; 95% CI, 0.77-1.57). During the anticoagulation course, factor V Leiden carriers had a similar risk for venous thromboembolism recurrence and half the risk for major bleeding compared with noncarriers. This finding may contribute to decision-making regarding anticoagulation duration in selected factor V Leiden carriers with venous thromboembolism. Tzoran I. aut Papadakis M. aut Brenner B. aut Fidalgo Á. aut Rivas A. aut Wells P.S. aut Gavín O. aut Adarraga M.D. aut Moustafa F. aut Monreal M. aut Decousus H. Prandoni P. Brenner B. Barba R. Di Micco P. Bertoletti L. Tzoran I. Reis A. Bosevski M. Bounameaux H. Malý R. Wells P. Papadakis M. Adarraga M.D. Aibar M.A. Alfonso M. Arcelus J.I. Barrón M. Barrón-Andrés B. Bascuñana J. Blanco-Molina A. Bueso T. Cañada G. Cañas I. Chic N. Del Pozo R. Del Toro J. Díaz-Pedroche M.C. Díaz-Peromingo J.A. Falgá C. Fernández-Capitán C. Fidalgo M.A. Font C. Font L. Gallego P. García A. García M.A. García-Bragado F. García-Brotons P. Gavín O. Gómez C. Gómez V. González J. González-Marcano D. Grau E. Grimón A. Guijarro R. Gutiérrez J. Hernández-Comes G. Hernández-Blasco L. Hermosa-Los Arcos M.J. Jara-Palomares L. Jaras M.J. Jiménez D. Joya M.D. Llamas P. Lecumberri R. Lobo J.L. López P. López-Jiménez L. López-Reyes R. López-Sáez J.B. Lorente M.A. Lorenzo A. Maestre A. Marchena P.J. Martín-Martos F. Monreal M. Nieto J.A. Nieto S. Núñez A. Núñez M.J. Odriozola M. Otero R. Pedrajas J.M. Pérez G. Pérez-Ductor C. Peris M.L. Porras J.A. Reig O. Riera-Mestre A. Riesco D. Rivas A. Rodríguez C. Rodríguez-Dávila M.A. Rosa V. Ruiz-Giménez N. Sahuquillo J.C. Sala-Sainz M.C. Sampériz A. Sánchez-Martínez R. Sánchez Simón-Talero R. Sanz O. Soler S. Suriñach J.M. Torres M.I. Trujillo-Santos J. Uresandi F. Valero B. Valle R. Vela J. Vicente M.P. Villalobos A. Vanassche T. Verhamme P. Hirmerova J. Tomko T. Del Pozo G. Salgado E. Sánchez G.T. Bura-Riviere A. Mahé I. Merah A. Moustafa F. Braester A. Antonucci G. Barillari G. Bilora F. Bortoluzzi C. Cattabiani C. Ciammaichella M. Di Biase J. Duce R. Ferrazzi P. Giorgi-Pierfranceschi M. Grandone E. Imbalzano E. Lodigiani C. Maida R. Mastroiacovo D. Pace F. Pesavento R. Pinelli M. Poggio R. Rota L. Tiraferri E. Tonello D. Tufano A. Visonà A. Zalunardo B. Gibietis V. Skride A. Vitola B. Monteiro P. Ribeiro J.L. Sousa M.S. Zdraveska M. Calanca L. Erdmann A. Mazzolai L. The American journal of medicine 130/4(2017-04), 482.e1-482.e9 130:4<482.e1-482.e9 2017 130 1 article serval SERVAL 700 1- Tzoran I. aut SERVAL 700 1- Papadakis M. aut SERVAL 700 1- Brenner B. aut SERVAL 700 1- Fidalgo Á. aut SERVAL 700 1- Rivas A. aut SERVAL 700 1- Wells P.S. aut SERVAL 700 1- Gavín O. aut SERVAL 700 1- Adarraga M.D. aut SERVAL 700 1- Moustafa F. aut SERVAL 700 1- Monreal M. aut SERVAL 700 1- Decousus H. SERVAL 700 1- Prandoni P. SERVAL 700 1- Brenner B. SERVAL 700 1- Barba R. SERVAL 700 1- Di Micco P. SERVAL 700 1- Bertoletti L. SERVAL 700 1- Tzoran I. SERVAL 700 1- Reis A. SERVAL 700 1- Bosevski M. SERVAL 700 1- Bounameaux H. SERVAL 700 1- Malý R. SERVAL 700 1- Wells P. SERVAL 700 1- Papadakis M. SERVAL 700 1- Adarraga M.D. SERVAL 700 1- Aibar M.A. SERVAL 700 1- Alfonso M. SERVAL 700 1- Arcelus J.I. SERVAL 700 1- Barrón M. SERVAL 700 1- Barrón-Andrés B. SERVAL 700 1- Bascuñana J. SERVAL 700 1- Blanco-Molina A. SERVAL 700 1- Bueso T. SERVAL 700 1- Cañada G. SERVAL 700 1- Cañas I. SERVAL 700 1- Chic N. SERVAL 700 1- Del Pozo R. SERVAL 700 1- Del Toro J. SERVAL 700 1- Díaz-Pedroche M.C. SERVAL 700 1- Díaz-Peromingo J.A. SERVAL 700 1- Falgá C. SERVAL 700 1- Fernández-Capitán C. SERVAL 700 1- Fidalgo M.A. SERVAL 700 1- Font C. SERVAL 700 1- Font L. SERVAL 700 1- Gallego P. SERVAL 700 1- García A. SERVAL 700 1- García M.A. SERVAL 700 1- García-Bragado F. SERVAL 700 1- García-Brotons P. SERVAL 700 1- Gavín O. SERVAL 700 1- Gómez C. SERVAL 700 1- Gómez V. SERVAL 700 1- González J. SERVAL 700 1- González-Marcano D. SERVAL 700 1- Grau E. SERVAL 700 1- Grimón A. SERVAL 700 1- Guijarro R. SERVAL 700 1- Gutiérrez J. SERVAL 700 1- Hernández-Comes G. SERVAL 700 1- Hernández-Blasco L. SERVAL 700 1- Hermosa-Los Arcos M.J. SERVAL 700 1- Jara-Palomares L. SERVAL 700 1- Jaras M.J. SERVAL 700 1- Jiménez D. SERVAL 700 1- Joya M.D. SERVAL 700 1- Llamas P. SERVAL 700 1- Lecumberri R. SERVAL 700 1- Lobo J.L. SERVAL 700 1- López P. SERVAL 700 1- López-Jiménez L. SERVAL 700 1- López-Reyes R. SERVAL 700 1- López-Sáez J.B. SERVAL 700 1- Lorente M.A. SERVAL 700 1- Lorenzo A. SERVAL 700 1- Maestre A. SERVAL 700 1- Marchena P.J. SERVAL 700 1- Martín-Martos F. SERVAL 700 1- Monreal M. SERVAL 700 1- Nieto J.A. SERVAL 700 1- Nieto S. SERVAL 700 1- Núñez A. SERVAL 700 1- Núñez M.J. SERVAL 700 1- Odriozola M. SERVAL 700 1- Otero R. SERVAL 700 1- Pedrajas J.M. SERVAL 700 1- Pérez G. SERVAL 700 1- Pérez-Ductor C. SERVAL 700 1- Peris M.L. SERVAL 700 1- Porras J.A. SERVAL 700 1- Reig O. SERVAL 700 1- Riera-Mestre A. SERVAL 700 1- Riesco D. SERVAL 700 1- Rivas A. SERVAL 700 1- Rodríguez C. SERVAL 700 1- Rodríguez-Dávila M.A. SERVAL 700 1- Rosa V. SERVAL 700 1- Ruiz-Giménez N. SERVAL 700 1- Sahuquillo J.C. SERVAL 700 1- Sala-Sainz M.C. SERVAL 700 1- Sampériz A. SERVAL 700 1- Sánchez-Martínez R. SERVAL 700 1- Sánchez Simón-Talero R. SERVAL 700 1- Sanz O. SERVAL 700 1- Soler S. SERVAL 700 1- Suriñach J.M. SERVAL 700 1- Torres M.I. SERVAL 700 1- Trujillo-Santos J. SERVAL 700 1- Uresandi F. SERVAL 700 1- Valero B. SERVAL 700 1- Valle R. SERVAL 700 1- Vela J. SERVAL 700 1- Vicente M.P. SERVAL 700 1- Villalobos A. SERVAL 700 1- Vanassche T. SERVAL 700 1- Verhamme P. SERVAL 700 1- Hirmerova J. SERVAL 700 1- Tomko T. SERVAL 700 1- Del Pozo G. SERVAL 700 1- Salgado E. SERVAL 700 1- Sánchez G.T. SERVAL 700 1- Bura-Riviere A. SERVAL 700 1- Mahé I. SERVAL 700 1- Merah A. SERVAL 700 1- Moustafa F. SERVAL 700 1- Braester A. SERVAL 700 1- Antonucci G. SERVAL 700 1- Barillari G. SERVAL 700 1- Bilora F. SERVAL 700 1- Bortoluzzi C. SERVAL 700 1- Cattabiani C. SERVAL 700 1- Ciammaichella M. SERVAL 700 1- Di Biase J. SERVAL 700 1- Duce R. SERVAL 700 1- Ferrazzi P. SERVAL 700 1- Giorgi-Pierfranceschi M. SERVAL 700 1- Grandone E. SERVAL 700 1- Imbalzano E. SERVAL 700 1- Lodigiani C. SERVAL 700 1- Maida R. SERVAL 700 1- Mastroiacovo D. SERVAL 700 1- Pace F. SERVAL 700 1- Pesavento R. SERVAL 700 1- Pinelli M. SERVAL 700 1- Poggio R. SERVAL 700 1- Rota L. SERVAL 700 1- Tiraferri E. SERVAL 700 1- Tonello D. SERVAL 700 1- Tufano A. SERVAL 700 1- Visonà A. SERVAL 700 1- Zalunardo B. SERVAL 700 1- Gibietis V. SERVAL 700 1- Skride A. SERVAL 700 1- Vitola B. SERVAL 700 1- Monteiro P. SERVAL 700 1- Ribeiro J.L. SERVAL 700 1- Sousa M.S. SERVAL 700 1- Zdraveska M. SERVAL 700 1- Calanca L. SERVAL 700 1- Erdmann A. SERVAL 700 1- Mazzolai L. SERVAL 773 0- The American journal of medicine 130/4(2017-04), 482.e1-482.e9 130:4<482.e1-482.e9 2017 130 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article