caa a22 4500 53021668X CHVBK 20190528032412.0 cr unu---uuuuu 181027e201810 xx s 000 0 eng 10.1002/JLB.4MR0118-038R doi (SERVAL)BIB_F183C2E25CDD 30020539 pmid 000445851000008 isiid Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity [Elektronische Daten] [J.C. Santos, P. Broz] Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with their replication complex. This association results in a restriction of the respective pathogen, yet the exact molecular mechanisms of the antimicrobial functions of GBPs are still unclear. Recent work has linked the GBPs with the activation of inflammasomes, multi-protein complexes that assemble upon recognition of pathogen- or host-derived signals and that drive the release of cytokines and host cell death. Here, we will focus on the most recent findings that have started to unravel the manifold restriction mechanism controlled by GBPs in mouse and human cells, and that shed light on the molecular cues that control GBP recruitment to bacterial membranes. Santos J.C. aut Broz P. aut Journal of leukocyte biology 104/4(2018-10), 729-735 104:4<729-735 2018 104 1 article serval SERVAL 700 1- Santos J.C. aut SERVAL 700 1- Broz P. aut SERVAL 773 0- Journal of leukocyte biology 104/4(2018-10), 729-735 104:4<729-735 2018 104 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article