caa a22 4500 530216779 CHVBK 20200302043031.0 cr unu---uuuuu 181027e20181012xx s 000 0 eng 10.1038/s41467-018-06453-1 doi (SERVAL)BIB_A5215CD5F4B5 30315166 pmid 000447123000028 isiid An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing [Elektronische Daten] [J.A. Sánchez-Alcañiz, A.F. Silbering, V. Croset, G. Zappia, A.K. Sivasubramaniam, L. Abuin, S.Y. Sahai, D. Münch, K. Steck, T.O. Auer, S. Cruchet, G.L. Neagu-Maier, S.G. Sprecher, C. Ribeiro, N. Yapici, R. Benton] Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations in diverse gustatory organs in larvae and adults. We characterise IR56d, which defines two anatomically-distinct neuron classes in the proboscis: one responds to carbonated solutions and fatty acids while the other represents a subset of sugar- and fatty acid-sensing cells. Mutational analysis indicates that IR56d, together with the broadly-expressed co-receptors IR25a and IR76b, is essential for physiological responses to carbonation and fatty acids, but not sugars. We further demonstrate that carbonation and fatty acids both promote IR56d-dependent attraction of flies, but through different behavioural outputs. Our work provides a toolkit for investigating taste functions of IRs, defines a subset of these receptors required for carbonation sensing, and illustrates how the gustatory system uses combinatorial expression of sensory molecules in distinct neurons to coordinate behaviour. Erratum with Publisher Correction: An Expression Atlas of Variant Ionotropic Glutamate Receptors Identifies a Molecular Basis of Carbonation Sensing JA Sánchez-Alcañiz et al. Nat Commun 11 (1), 1131. 2020. PMID 32098953. Sánchez-Alcañiz J.A. aut Silbering A.F. aut Croset V. aut Zappia G. aut Sivasubramaniam A.K. aut Abuin L. aut Sahai S.Y. aut Münch D. aut Steck K. aut Auer T.O. aut Cruchet S. aut Neagu-Maier G.L. aut Sprecher S.G. aut Ribeiro C. aut Yapici N. aut Benton R. aut Nature communications 9/1(2018-10-12), 4252 9:1<4252 2018 9 1 article serval SERVAL 700 1- Sánchez-Alcañiz J.A. aut SERVAL 700 1- Silbering A.F. aut SERVAL 700 1- Croset V. aut SERVAL 700 1- Zappia G. aut SERVAL 700 1- Sivasubramaniam A.K. aut SERVAL 700 1- Abuin L. aut SERVAL 700 1- Sahai S.Y. aut SERVAL 700 1- Münch D. aut SERVAL 700 1- Steck K. aut SERVAL 700 1- Auer T.O. aut SERVAL 700 1- Cruchet S. aut SERVAL 700 1- Neagu-Maier G.L. aut SERVAL 700 1- Sprecher S.G. aut SERVAL 700 1- Ribeiro C. aut SERVAL 700 1- Yapici N. aut SERVAL 700 1- Benton R. aut SERVAL 773 0- Nature communications 9/1(2018-10-12), 4252 9:1<4252 2018 9 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article