caa a22 4500 530216892 CHVBK 20190303134236.0 cr unu---uuuuu 181027e20181005xx s 000 0 eng 10.1038/s41467-018-06517-2 doi (SERVAL)BIB_61D309216459 30291233 pmid 000446493300004 isiid A rapid rate of sex-chromosome turnover and non-random transitions in true frogs [Elektronische Daten] [D.L. Jeffries, G. Lavanchy, R. Sermier, M.J. Sredl, I. Miura, A. Borzée, L.N. Barrow, D. Canestrelli, P.A. Crochet, C. Dufresnes, J. Fu, W.J. Ma, C.M. Garcia, K. Ghali, A.G. Nicieza, R.P. O'Donnell, N. Rodrigues, A. Romano, Í. Martínez-Solano, I. Stepanyan, S. Zumbach, A. Brelsford, N. Perrin] The canonical model of sex-chromosome evolution predicts that, as recombination is suppressed along sex chromosomes, gametologs will progressively differentiate, eventually becoming heteromorphic. However, there are numerous examples of homomorphic sex chromosomes across the tree of life. This homomorphy has been suggested to result from frequent sex-chromosome turnovers, yet we know little about which forces drive them. Here, we describe an extremely fast rate of turnover among 28 species of Ranidae. Transitions are not random, but converge on several chromosomes, potentially due to genes they harbour. Transitions also preserve the ancestral pattern of male heterogamety, in line with the 'hot-potato' model of sex-chromosome transitions, suggesting a key role for mutation-load accumulation in non-recombining genomic regions. The importance of mutation-load selection in frogs might result from the extreme heterochiasmy they exhibit, making frog sex chromosomes differentiate immediately from emergence and across their entire length. Jeffries D.L. aut Lavanchy G. aut Sermier R. aut Sredl M.J. aut Miura I. aut Borzée A. aut Barrow L.N. aut Canestrelli D. aut Crochet P.A. aut Dufresnes C. aut Fu J. aut Ma W.J. aut Garcia C.M. aut Ghali K. aut Nicieza A.G. aut O'Donnell R.P. aut Rodrigues N. aut Romano A. aut Martínez-Solano Í. aut Stepanyan I. aut Zumbach S. aut Brelsford A. aut Perrin N. aut Nature communications 9/1(2018-10-05), 4088 9:1<4088 2018 9 1 article serval SERVAL 700 1- Jeffries D.L. aut SERVAL 700 1- Lavanchy G. aut SERVAL 700 1- Sermier R. aut SERVAL 700 1- Sredl M.J. aut SERVAL 700 1- Miura I. aut SERVAL 700 1- Borzée A. aut SERVAL 700 1- Barrow L.N. aut SERVAL 700 1- Canestrelli D. aut SERVAL 700 1- Crochet P.A. aut SERVAL 700 1- Dufresnes C. aut SERVAL 700 1- Fu J. aut SERVAL 700 1- Ma W.J. aut SERVAL 700 1- Garcia C.M. aut SERVAL 700 1- Ghali K. aut SERVAL 700 1- Nicieza A.G. aut SERVAL 700 1- O'Donnell R.P. aut SERVAL 700 1- Rodrigues N. aut SERVAL 700 1- Romano A. aut SERVAL 700 1- Martínez-Solano Í. aut SERVAL 700 1- Stepanyan I. aut SERVAL 700 1- Zumbach S. aut SERVAL 700 1- Brelsford A. aut SERVAL 700 1- Perrin N. aut SERVAL 773 0- Nature communications 9/1(2018-10-05), 4088 9:1<4088 2018 9 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article