caa a22 4500 55131642X CHVBK 20200106043605.0 cr unu---uuuuu 181213e201901 xx s 000 0 eng 10.1002/mrm.27384 doi (SERVAL)BIB_70EE80048D23 30024061 pmid 000454009000022 isiid Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI [Elektronische Daten] [M. Schär, S. Soleimanifard, G. Bonanno, J. Yerly, A.G. Hays, R.G. Weiss] Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross-sectional area changes in response to isometric handgrip exercise, an endothelial-dependent stressor. Area changes (10 to 20% in healthy; 2 to -12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations and phantom studies, we test whether Fourier interpolation enables sub-pixel area measurement precision and determine the smallest detectable area change using spiral MRI. In vivo coronary SNR with the currently used CEF protocol at 3T was measured in 7 subjects for subsequent in vitro work. Area measurements of circular vessels were simulated by varying partial volume, vessel diameter, voxel size, SNR, and Fourier interpolation factor. A phantom with precision-drilled holes (diameters 3-3.42 mm) was imaged 10 times with the current CEF protocol (voxel size, Δx = 0.89 mm) and a high-resolution protocol (Δx = 0.6 mm) to determine precision, accuracy, and the smallest detectable area changes. In vivo coronary SNR ranged from 30-76. Eight-fold Fourier interpolation improved area measurement precision by a factor 6.5 and 4.9 in the simulations and phantom scans, respectively. The current CEF protocol can detect mean area changes of 4-5% for SNR above 30, and 3-3.5% for SNR above 40 with a higher-resolution protocol. Current CEF spiral MRI with in vivo SNR allows detection of a 4-5% area change and Fourier interpolation improves precision several-fold to sub-voxel dimensions. Schär M. aut Soleimanifard S. aut Bonanno G. aut Yerly J. aut Hays A.G. aut Weiss R.G. aut Magnetic resonance in medicine 81/1(2019-01), 291-302 81:1<291-302 2019 81 1 article serval SERVAL 700 1- Schär M. aut SERVAL 700 1- Soleimanifard S. aut SERVAL 700 1- Bonanno G. aut SERVAL 700 1- Yerly J. aut SERVAL 700 1- Hays A.G. aut SERVAL 700 1- Weiss R.G. aut SERVAL 773 0- Magnetic resonance in medicine 81/1(2019-01), 291-302 81:1<291-302 2019 81 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article