caa a22 4500 551316640 CHVBK 20181219042044.0 cr unu---uuuuu 181213s2018 xx s 000 0 eng 10.1016/j.mrrev.2018.09.001 doi (SERVAL)BIB_262474A97CC4 30454681 pmid 000451491400004 isiid Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance [Elektronische Daten] [B. Siddeek, C. Mauduit, U. Simeoni, M. Benahmed] Paternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of offspring to develop diseases such as cancer, metabolic, cardiovascular, and neurological diseases. These data were confirmed and deepened in animal models of exposure to challenges including low-protein, low-folate, high-fat diets, exposure to chemicals such as pesticides and herbicides. Even though some toxicants have mutagenic effect on sperm DNA, changes in sperm epigenome seem to be a common thread between different types of challenges. Indeed, epigenetic changes (DNA methylation, chromatin remodeling, small non-coding RNA) in sperm are described as new mechanisms of intergenerational transmission as demonstrated for dioxin, for example. Those epimutations induce dysregulation in genes expression involved in key cellular pathways such as reactive oxygen species and genome stability regulation, in brain-derived neurotrophic factor, calcium and glucocorticoid signaling, and in lipid and glucose metabolism, leading to diseases in offspring. Finally, since each type of environmental challenges has its own signature by inducing epimutations at specific genomic loci, the sperm epigenome might be used as a biomarker in toxicological and risk assessments. Siddeek B. aut Mauduit C. aut Simeoni U. aut Benahmed M. aut Mutation research 778(2018), 38-44 778<38-44 2018 778 1 article serval SERVAL 700 1- Siddeek B. aut SERVAL 700 1- Mauduit C. aut SERVAL 700 1- Simeoni U. aut SERVAL 700 1- Benahmed M. aut SERVAL 773 0- Mutation research 778(2018), 38-44 778<38-44 2018 778 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article