caa a22 4500 551316659 CHVBK 20190327044938.0 cr unu---uuuuu 181213e201904 xx s 000 0 eng 10.1111/ene.13868 doi (SERVAL)BIB_38B22CAEC6DF 30431216 pmid 000460307300015 isiid Diagnostic usefulness of plexus magnetic resonance imaging in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination [Elektronische Daten] [G. Fargeot, K. Viala, M. Theaudin, M.A. Labeyrie, R. Costa, J.M. Léger, D. Adams, C. Vandendries, C. Labeyrie] The usefulness of plexus magnetic resonance imaging (MRI) in the diagnosis of chronic inflammatory demyelinating polyradiculopathy (CIDP) without definite European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) electrodiagnostic criteria is currently unclear. Data from consecutive patients with clinical manifestations suggesting CIDP, with or without (CIDP-D and CIDP-ND, respectively) definite EFNS/PNS electrodiagnostic criteria, and referred for plexus MRI in our imaging centre were retrospectively analysed. An expert committee of neurologists compared the level of suspicion of CIDP in CIDP-ND patients to the blinded/unblinded MRI findings. Plexus MRI was reviewed by a neuroradiologist blinded to the final diagnosis. In all, 38 patients were assessed with suspected CIDP-ND [7/38 (18%) probable; 13/38 (34%) possible; 18/38 (47%), no EFNS/PNS electrodiagnostic criteria], plus 10 with CIDP-D. Thirty-six of the 38 (95%) fulfilled clinical criteria of CIDP variants, including pure sensory neuropathy in 22/36 (61%). Plexus MRI showed abnormalities in 22/38 (58%) patients including increased nerve signal intensity on T2-weighted images in 22/22 (100%), nerve enlargement in 20/22 (91%) and contrast enhancement in 8/22 (36%). Plexus MRI enabled the expert committee's final diagnosis to be adjusted in 7/38 (18%) patients, and in conjunction with nerve conduction studies was a supportive criterion to classify 7/24 (29%) patients as definite CIDP. MRI abnormalities were more asymmetrical (P = 0.03) and less diffuse (P = 0.1) in CIDP-ND than in CIDP-D. Our observations suggest that plexus MRI makes a valuable contribution to the diagnosis of CIDP-ND patients. Further studies are needed to investigate inter-rater reliability of clinical and imaging criteria of CIDP in these patients, and the impact on outcomes. Fargeot G. aut Viala K. aut Theaudin M. aut Labeyrie M.A. aut Costa R. aut Léger J.M. aut Adams D. aut Vandendries C. aut Labeyrie C. aut European journal of neurology 26/4(2019-04), 631-638 26:4<631-638 2019 26 1 article serval SERVAL 700 1- Fargeot G. aut SERVAL 700 1- Viala K. aut SERVAL 700 1- Theaudin M. aut SERVAL 700 1- Labeyrie M.A. aut SERVAL 700 1- Costa R. aut SERVAL 700 1- Léger J.M. aut SERVAL 700 1- Adams D. aut SERVAL 700 1- Vandendries C. aut SERVAL 700 1- Labeyrie C. aut SERVAL 773 0- European journal of neurology 26/4(2019-04), 631-638 26:4<631-638 2019 26 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article