cam a22 4500 551371684 CHVBK 20201114033944.0 m d cr |n |||||||| 160908t20172017nyu sb 001 0 eng d 2016024105 978-0-19-065124-4 (hardback : acidfree paper) 0-19-065124-5 (hardback : acidfree paper) 978-0-19-065126-8 (ebook) 978-0-19-065127-5 (online resource) (SERSOL)ssj0001751129 (WaSeSS)ssj0001751129 DLC eng DLC DLC WaSeSS rda QR181 .T37 2017 616.07/9 23 SCI075000 MED044000 bisacsh Tauber Alfred I. Immunity the evolution of an idea Alfred I. Tauber New York, NY, United States of America Oxford University Press [2017] ©2017 1 online resource (xx, 303 pages) text txt rdacontent/eng computer c rdamedia/eng online resource cr rdacarrier/eng Includes bibliographical references and index. Machine generated contents note: -- Preface -- Acknowledgements -- Introduction -- Chapter 1: A History of the Immune Self -- Chapter 2: Whither Immune Identity? -- Chapter 3: Individuality Revised -- Chapter 4: Immune Cognition -- Chapter 5: Eco-immunology -- Chapter 6: A New Biology? -- Epilogue -- Endnotes -- References.650 Lizenzbedingungen können den Zugang einschränken. License restrictions may limit access. "Senior scholar Alfred Tauber argues in this bold account that common approaches to the study of immunology are inherently flawed in its strict dichotomy of the self and non-self, or external invaders. The relationship between what is self and what is non-self is in reality a complex, dynamic, relational one. Autonomous agents are constantly in the midst of dialectical exchanges in which immunity mediates both noxious and benign encounters. Namely: rather than serving to defend an independent entity, immunity participates in an eco-system. Contemporary transplantation biology and autoimmunity have demonstrated phenomena that upset rigid adherence to the self/non-self dichotomy. Placing tolerant immune mechanisms within a broad ecological context has highlighted the balance of co-operative and competitive relationships in which immunity functions. By understanding immunity this way, as a 'symbiotic turn,' we come to see that immune reactivity (rejection or tolerance) is a second-order response to the cognitive functions of the immune system. Organisms have a complex capacity to respond to environment, and, through Tauber's insignts, we appreciate them more fully when we grasp the flexibility of the borders of organisms. After first providing an overview of the history of immunology, and explaining why the dominant understanding of it is incomplete and limiting, Tauber argues for this new approach to immunology and explains how it will usher in a new biology in which symbiosis is the rule, not the exception."-- "Immunity mediates both defensive and cooperative relations with the environment. Therefore, the traditional focus on host defense misconstrues the full spectrum of immune activities. An alternate model based on immune balance highlights the information processing of immune perception that precedes discriminatory decisions -- to reject, assimilate, or ignore the identified object"-- Immunology Philosophy SCIENCE / Philosophy & Social Aspects bisacsh MEDICAL / Immunology bisacsh http://dx.doi.org/10.1093/acprof:oso/9780190651244.001.0001 Uni Basel: Volltext https://oxford.universitypressscholarship.com/view/10.1093/acprof:oso/9780190651244.001.0001/acprof-9780190651244 Uni Bern: Volltext BK020053 XK020053 XK020000 Oxford Scholarship Online Philosophy Collection 2016-2017 E-Books von 360MarcUpdates Oxford Scholarship Online IDSBB A145 A145 145VT NELA1451802 IDSBB B405 B405 405VT NELB4052004 IDSBB 100 1- Tauber Alfred I. IDSBB 856 40 http://dx.doi.org/10.1093/acprof:oso/9780190651244.001.0001 Uni Basel: Volltext IDSBB 856 40 https://oxford.universitypressscholarship.com/view/10.1093/acprof:oso/9780190651244.001.0001/acprof-9780190651244 Uni Bern: Volltext SWISSBIB 491278888