cad a22 4500 551414693 20190604061643.0 cr unu---uuuuu 181214e20181201xx s 000 0 eng 10.5167/uzh-159385 doi 10.1038/s41598-018-34002-9 doi (ZORA)oai:www.zora.uzh.ch:159385 610 ddc 30361495 pmid Sensorimotor stroke alters hippocampo-thalamic network activity [Elektronische Daten] [Philipp Baumgartner, Mohamad El Amki, Oliver Bracko, Andreas R Luft, Susanne Wegener] openAccess eu-repo Many stroke survivors experience persisting episodic memory disturbances. Since hippocampal and para-hippocampal areas are usually spared from the infarcted area, alterations of memory processing networks remote from the ischemic brain region might be responsible for the observed clinical symptoms. To pinpoint changes in activity of hippocampal connections and their role in post-stroke cognitive impairment, we induced ischemic stroke by occlusion of the middle cerebral artery (MCAO) in adult rats and analyzed the functional and structural consequences using activity-dependent manganese (Mn2+) enhanced MRI (MEMRI) along with behavioral and histopathological analysis. MCAO caused stroke lesions of variable extent along with sensorimotor and cognitive deficits. Direct hippocampal injury occurred in some rats, but was no prerequisite for cognitive impairment. In healthy rats, injection of Mn2+ into the entorhinal cortex resulted in distribution of the tracer within the hippocampal subfields into the lateral septal nuclei. In MCAO rats, Mn2+ accumulated in the ipsilateral thalamus. Histopathological analysis revealed secondary thalamic degeneration 28 days after stroke. Our findings provide in vivo evidence that remote sensorimotor stroke modifies the activity of hippocampal-thalamic networks. In addition to potentially reversible alterations in signaling of these connections, structural damage of the thalamus likely reinforces dysfunction of hippocampal-thalamic circuitries. Clinic for Neurology zora Neuroscience Center Zurich zora Multidisciplinary zora Baumgartner Philipp joint author El Amki Mohamad joint author Bracko Oliver joint author Luft Andreas R. joint author Wegener Susanne joint author Scientific Reports 8:15770 https://www.zora.uzh.ch/id/eprint/159385/1/ScieRep_Baumgartner_Mangan2018.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora SNSF/Projectfunding/PMPDP3_145470/CH zora grantAgreement ZORA 856 40 https://www.zora.uzh.ch/id/eprint/159385/1/ScieRep_Baumgartner_Mangan2018.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Baumgartner Philipp joint author ZORA 700 1- El Amki Mohamad joint author ZORA 700 1- Bracko Oliver joint author ZORA 700 1- Luft Andreas R. joint author ZORA 700 1- Wegener Susanne joint author ZORA 773 0- Scientific Reports 8:15770 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess