caa a22 4500 551458232 CHVBK 20190806032432.0 cr unu---uuuuu 181215e201812 xx s 000 0 eng 10.1016/j.conb.2018.08.007 doi (SERVAL)BIB_0A03412C79E3 30241058 pmid 000451938500023 isiid Maintenance mechanisms of circuit-integrated axons [Elektronische Daten] [V. Mariano, N. Domínguez-Iturza, L.J. Neukomm, C. Bagni] Adult, circuit-integrated neurons must be maintained and supported for the life span of their host. The attenuation of either maintenance or plasticity leads to impaired circuit function and ultimately to neurodegenerative disorders. Over the last few years, significant discoveries of molecular mechanisms were made that mediate the formation and maintenance of axons. Here, we highlight intrinsic and extrinsic mechanisms that ensure the health and survival of axons. We also briefly discuss examples of mutations associated with impaired axonal maintenance identified in specific neurological conditions. A better understanding of these mechanisms will therefore help to define targets for therapeutic interventions. Mariano V. aut Domínguez-Iturza N. aut Neukomm L.J. aut Bagni C. aut Current opinion in neurobiology 53(2018-12), 162-173 53<162-173 2018 53 1 article serval SERVAL 700 1- Mariano V. aut SERVAL 700 1- Domínguez-Iturza N. aut SERVAL 700 1- Neukomm L.J. aut SERVAL 700 1- Bagni C. aut SERVAL 773 0- Current opinion in neurobiology 53(2018-12), 162-173 53<162-173 2018 53 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article