caa a22 4500 551458429 CHVBK 20190303132528.0 cr unu---uuuuu 181215e201812 xx s 000 0 eng 10.1097/NMD.0000000000000905 doi (SERVAL)BIB_F027F2F4CB34 30507735 pmid 000452972000005 isiid Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study [Elektronische Daten] [U. Kramer, S. Kolly, P. Maillard, A. Pascual-Leone, A.C. Samson, R. Schmitt, A. Bernini, G. Allenbach, P. Charbon, Y. de Roten, P. Conus, J.N. Despland, B. Draganski] Changes in emotional processing (EP) and in theory of mind (TOM) are central across treatment approaches for patients with borderline personality disorder (BPD). Although the assessment of EP relies on the observation of a patient's self-criticism in a two-chair dialogue, an individual's TOM assessments is made based on responses to humorous stimuli based on false beliefs. For this pilot study, we assessed eight patients with BPD before and after a 3-month-long psychiatric treatment, using functional magnetic resonance imaging and behavioral tasks. We observed arousal increase within the session of the two-chair dialogue (d = 0.36), paralleled by arousal decrease between sessions (d = 0.80). We found treatment-associated trends for neural activity reduction in brain areas central for EP and TOM. Our exploratory findings using an integrative assessment procedure of changes in EP and TOM point toward evidence for treatment effects at the brain systems level related to behavioral modulation. Kramer U. aut Kolly S. aut Maillard P. aut Pascual-Leone A. aut Samson A.C. aut Schmitt R. aut Bernini A. aut Allenbach G. aut Charbon P. aut de Roten Y. aut Conus P. aut Despland J.N. aut Draganski B. aut The Journal of nervous and mental disease 206/12(2018-12), 935-943 206:12<935-943 2018 206 1 article serval SERVAL 700 1- Kramer U. aut SERVAL 700 1- Kolly S. aut SERVAL 700 1- Maillard P. aut SERVAL 700 1- Pascual-Leone A. aut SERVAL 700 1- Samson A.C. aut SERVAL 700 1- Schmitt R. aut SERVAL 700 1- Bernini A. aut SERVAL 700 1- Allenbach G. aut SERVAL 700 1- Charbon P. aut SERVAL 700 1- de Roten Y. aut SERVAL 700 1- Conus P. aut SERVAL 700 1- Despland J.N. aut SERVAL 700 1- Draganski B. aut SERVAL 773 0- The Journal of nervous and mental disease 206/12(2018-12), 935-943 206:12<935-943 2018 206 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article