caa a22 4500 555159159 CHVBK 20190604032324.0 cr unu---uuuuu 190202e201905 xx s 000 0 eng 10.1007/s00198-018-04820-8 doi (SERVAL)BIB_0954776AB6A8 30613866 pmid 000467142400020 isiid Alendronate after denosumab discontinuation in women previously exposed to bisphosphonates was not effective in preventing the risk of spontaneous multiple vertebral fractures: two case reports [Elektronische Daten] [O. Lamy, E. Fernández-Fernández, I. Monjo-Henry, D. Stoll, B. Aubry-Rozier, D. Benavent-Núñez, P. Aguado, E. Gonzalez-Rodriguez] At denosumab discontinuation, an antiresorptive agent is indicated to reduce the high bone turnover, the rapid bone loss, and the risk of spontaneous vertebral fractures. We report two cases of postmenopausal women, previously exposed to bisphosphonates, treated with alendronate at denosumab discontinuation. Alendronate was ineffective to avoid spontaneous clinical vertebral fractures. They presented three and nine spontaneous vertebral fractures 8 and 12months after denosumab discontinuation, respectively. Ineffectiveness of alendronate was attributed to insufficient control of the rebound as assessed by B-crosslaps measures in the first case, and partially to the high risk of fractures in the later. In both situations, the increased fracture risk may have favoured these new fractures. It is urgent to define effective therapeutic strategies to avoid spontaneous vertebral fractures after denosumab discontinuation. Lamy O. aut Fernández-Fernández E. aut Monjo-Henry I. aut Stoll D. aut Aubry-Rozier B. aut Benavent-Núñez D. aut Aguado P. aut Gonzalez-Rodriguez E. aut Osteoporosis international 30/5(2019-05), 1111-1115 30:5<1111-1115 2019 30 1 article serval SERVAL 700 1- Lamy O. aut SERVAL 700 1- Fernández-Fernández E. aut SERVAL 700 1- Monjo-Henry I. aut SERVAL 700 1- Stoll D. aut SERVAL 700 1- Aubry-Rozier B. aut SERVAL 700 1- Benavent-Núñez D. aut SERVAL 700 1- Aguado P. aut SERVAL 700 1- Gonzalez-Rodriguez E. aut SERVAL 773 0- Osteoporosis international 30/5(2019-05), 1111-1115 30:5<1111-1115 2019 30 BK010053 XK010053 XK010000 SERVAL SERVAL SERVAL article