caa a22 4500 555243893 20201130031324.0 cr unu---uuuuu 190205s2018 xx s 000 0 eng (BORIS)oai:boris.unibe.ch:122960 610 ddc Advances in therapeutic options for portal hypertension [Elektronische Daten] [Marina Vilaseca, Sergi Guixé Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho] publishedVersion openAccess eu-repo Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. The present review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms. Vilaseca Marina joint author Guixé Muntet Sergi joint author Fernández-Iglesias Anabel joint author Gracia-Sancho Jordi joint author Therapeutic advances in gastroenterology 11, p. 1756284818811294 Onlinezugriff via WWW text/html Vilaseca, Marina; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Gracia-Sancho, Jordi (2018). Advances in therapeutic options for portal hypertension. Therapeutic advances in gastroenterology, 11, p. 1756284818811294. Sage 10.1177/1756284818811294 <http://dx.doi.org/10.1177/1756284818811294> BORIS BK010053 XK010053 XK010000 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS BORIS BORIS info:eu-repo/semantics/article openAccess BORIS 856 42 Onlinezugriff via WWW text/html Vilaseca, Marina; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Gracia-Sancho, Jordi (2018). Advances in therapeutic options for portal hypertension. Therapeutic advances in gastroenterology, 11, p. 1756284818811294. Sage 10.1177/1756284818811294 <http://dx.doi.org/10.1177/1756284818811294> BORIS 700 1- Vilaseca Marina joint author BORIS 700 1- Guixé Muntet Sergi joint author BORIS 700 1- Fernández-Iglesias Anabel joint author BORIS 700 1- Gracia-Sancho Jordi joint author BORIS 773 0- Therapeutic advances in gastroenterology 11, p. 1756284818811294