naa a22 4500 555243931 20190205064556.0 cr unu---uuuuu 190205e201801 xx s 000 0 eng 0014-2980 10.1002/eji.201747100 doi (BORIS)oai:boris.unibe.ch:122996 610 ddc 28875499 pmid The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice [Elektronische Daten] [Jakob Zimmermann, Pawel Durek, Anja A Kühl, Florian Schattenberg, Patrick Maschmeyer, Francesco Siracusa, Katrin Lehmann, Kerstin Westendorf, Melanie Weber, René Riedel, Susann Müller, Andreas Radbruch, Hyun-Dong Chang] publishedVersion openAccess eu-repo Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation. Zimmermann Jakob joint author Durek Pawel joint author Kühl Anja A. joint author Schattenberg Florian joint author Maschmeyer Patrick joint author Siracusa Francesco joint author Lehmann Katrin joint author Westendorf Kerstin joint author Weber Melanie joint author Riedel René joint author Müller Susann joint author Radbruch Andreas joint author Chang Hyun-Dong joint author European journal of immunology 48(1), pp. 161-167 0014-2980 https://boris.unibe.ch/122996/1/EJI-48-161.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/122996/1/EJI-48-161.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Zimmermann Jakob joint author BORIS 700 1- Durek Pawel joint author BORIS 700 1- Kühl Anja A. joint author BORIS 700 1- Schattenberg Florian joint author BORIS 700 1- Maschmeyer Patrick joint author BORIS 700 1- Siracusa Francesco joint author BORIS 700 1- Lehmann Katrin joint author BORIS 700 1- Westendorf Kerstin joint author BORIS 700 1- Weber Melanie joint author BORIS 700 1- Riedel René joint author BORIS 700 1- Müller Susann joint author BORIS 700 1- Radbruch Andreas joint author BORIS 700 1- Chang Hyun-Dong joint author BORIS 773 0- European journal of immunology 48(1), pp. 161-167 0014-2980 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess