cad a22 4500 55525934X 20190502033206.0 cr unu---uuuuu 190205e201804 xx s 000 0 eng 10.5167/uzh-161573 doi 10.1097/INF.0000000000001894 doi (ZORA)oai:www.zora.uzh.ch:161573 610 ddc 29329169 pmid Differences in Immunization Site Pain in Toddlers Vaccinated With Either the 10- or the 13-Valent Pneumococcal Conjugate Vaccine [Elektronische Daten] [Johannes Trück, Sarah Kelly, Sena Jawad, Matthew D Snape, Merryn Voysey, Andrew J Pollard] openAccess eu-repo BACKGROUND Immunization site pain is a common and unpleasant experience for both children and adults. It is a source of anxiety and distress and may ultimately result in nonadherence to vaccination schedules. There is limited information on how different brands of vaccines affect the intensity of immediate pain at the time of vaccine injection. METHODS Children in the United Kingdom (n = 178) were randomized to receive a booster dose of either the 10- or the 13-valent pneumococcal conjugate vaccine (PCV-10 or PCV-13). Immediate immunization site pain was assessed using validated pain assessment tools and crying time to investigate factors that may interfere with parental compliance to vaccination. RESULTS Pain measurements were available for n ≥ 74 and n ≥ 78 PCV-10 and PCV-13 recipients, respectively. PCV-13 recipients had significantly higher scores on the observer-rated modified behavioral pain scale than did those receiving PCV-10. No significant differences in the induction of pain between the 2 vaccines were found when a parent-rated pain assessment tool or crying time was used. CONCLUSIONS PCV-10 administration was associated with slightly less acute pain compared with the injection of PCV-13, but the size of the difference was small and is of unknown clinical significance. Medical Clinic zora Trück Johannes joint author Kelly Sarah joint author Jawad Sena joint author Snape Matthew D. joint author Voysey Merryn joint author Pollard Andrew J. joint author The Pediatric Infectious Disease Journal 37(4):e103-e106 https://www.zora.uzh.ch/id/eprint/161573/1/Differences_in_Immunization_Site_Pain_in_Toddlers.20.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/161573/1/Differences_in_Immunization_Site_Pain_in_Toddlers.20.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Trück Johannes joint author ZORA 700 1- Kelly Sarah joint author ZORA 700 1- Jawad Sena joint author ZORA 700 1- Snape Matthew D. joint author ZORA 700 1- Voysey Merryn joint author ZORA 700 1- Pollard Andrew J. joint author ZORA 773 0- The Pediatric Infectious Disease Journal 37(4):e103-e106 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess