caa a22 4500 555285235 20200402030200.0 cr unu---uuuuu 190206e20190109xx s 000 0 eng 1929-0748 10.2196/12270 doi (BORIS)oai:boris.unibe.ch:123623 610 ddc 570 ddc 30626571 pmid Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study [Elektronische Daten] [Suyi Hu, Lukas Peter Anschütz, Markus Huth, Raphael Sznitman, Daniela Blaser, Martin Kompis, Deborah A Hall, Marco Caversaccio, Wilhelm Wimmer] publishedVersion openAccess eu-repo BACKGROUND Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the interpretation of previous findings. OBJECTIVE This study aims to investigate the feasibility of EEG measurements as an objective indicator for the identification of tinnitus-associated neural activities. METHODS To reduce heterogeneity, participants served as their own control using residual inhibition (RI) to modulate the tinnitus perception in a within-subject EEG study design with a tinnitus group. In addition, comparison with a nontinnitus control group allowed for a between-subjects comparison. We will apply RI stimulation to generate tinnitus and nontinnitus conditions in the same subject. Furthermore, high-frequency audiometry (up to 13 kHz) and tinnitometry will be performed. RESULTS This work was funded by the Infrastructure Grant of the University of Bern, Bern, Switzerland and Bernafon AG, Bern, Switzerland. Enrollment for the study described in this protocol commenced in February 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in 2019. CONCLUSIONS This study design helps in comparing the neural activity between conditions in the same individual, thereby addressing a notable limitation of previous EEG tinnitus studies. In addition, the high-frequency assessment will help to analyze and classify tinnitus symptoms beyond the conventional clinical standard. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) RR1-10.2196/12270. Hu Suyi joint author Anschütz Lukas Peter joint author Huth Markus joint author Sznitman Raphael joint author Blaser Daniela joint author Kompis Martin joint author Hall Deborah A. joint author Caversaccio Marco joint author Wimmer Wilhelm joint author JMIR research protocols 8(1), e12270 1929-0748 https://boris.unibe.ch/123623/1/2f49d436-43c6-4988-b4f7-4be0d917373d.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/123623/1/2f49d436-43c6-4988-b4f7-4be0d917373d.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Hu Suyi joint author BORIS 700 1- Anschütz Lukas Peter joint author BORIS 700 1- Huth Markus joint author BORIS 700 1- Sznitman Raphael joint author BORIS 700 1- Blaser Daniela joint author BORIS 700 1- Kompis Martin joint author BORIS 700 1- Hall Deborah A. joint author BORIS 700 1- Caversaccio Marco joint author BORIS 700 1- Wimmer Wilhelm joint author BORIS 773 0- JMIR research protocols 8(1), e12270 1929-0748 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess