cad a22 4500 555301230 20200201045349.0 cr unu---uuuuu 190206e20190401xx s 000 0 eng 10.5167/uzh-161769 doi 10.1002/jbio.201800300 doi (ZORA)oai:www.zora.uzh.ch:161769 610 ddc 30379410 pmid Characterization of the optical properties of color pastes for the design of optical phantoms mimicking biological tissue [Elektronische Daten] [Natasha Tomm, Linda Ahnen, Helene Isler, Stefan Kleiser, Tanja Karen, Daniel Ostojic, Martin Wolf, Felix Scholkmann] openAccess eu-repo Clinicians need a way to rapidly and reliably test the correct functioning of near-infrared spectroscopy (NIRS)-based oximeters. Therefore, optical phantoms for quality assessment of NIRS oximeters are needed. The fabrication of such phantoms that mimic the optical properties of biological tissue in the NIR range represents a challenge. To enable their development, the aim was to characterize the absorption and scattering spectra of different dyes. The optical properties of silicone SILPURAN 2420 with 11 color pastes of type ELASTOSIL were measured in the 500 to 1000 nm range by a spectrometer with an integrating sphere. In addition, two commercial frequency-domain NIRS devices, the ISS OxiplexTS and the ISS Imagent, were used to assess the optical properties at specific wavelengths. The evaluated colors present mostly features in the visible range below 650 nm, but two colors include peaks in the near-infrared region, simulating low tissue oxygenation values. These colors were used to create an optical phantom, which matched the designed StO value within an error of only 4%. This set of dyes already enables simulating many different spectra, thus achieving a first step on the way to a long-term stable comparison and validation method. Clinic for Neonatology zora Tomm Natasha joint author Ahnen Linda joint author Isler Helene joint author Kleiser Stefan joint author Karen Tanja joint author Ostojic Daniel joint author Wolf Martin joint author Scholkmann Felix joint author Journal of Biophotonics 12(4):e201800300 https://www.zora.uzh.ch/id/eprint/161769/1/Tomm_Ahnen_silicone_dyes_JPB_2018_Neo_USZ.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/161769/1/Tomm_Ahnen_silicone_dyes_JPB_2018_Neo_USZ.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Tomm Natasha joint author ZORA 700 1- Ahnen Linda joint author ZORA 700 1- Isler Helene joint author ZORA 700 1- Kleiser Stefan joint author ZORA 700 1- Karen Tanja joint author ZORA 700 1- Ostojic Daniel joint author ZORA 700 1- Wolf Martin joint author ZORA 700 1- Scholkmann Felix joint author ZORA 773 0- Journal of Biophotonics 12(4):e201800300 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess