nad a22 4500 555301826 20190206082643.0 cr unu---uuuuu 190206s2018 xx s 000 0 eng 10.5167/uzh-166269 doi 10.3389/fcvm.2018.00074 doi (ZORA)oai:www.zora.uzh.ch:166269 610 ddc 29971238 pmid Transcatheter Aortic Valve Replacement and Concomitant Mitral Regurgitation [Elektronische Daten] [Barbara E Stähli, Markus Reinthaler, David M Leistner, Ulf Landmesser, Alexander Lauten] openAccess eu-repo Mitral regurgitation frequently coexists in patients with severe aortic stenosis. Patients with moderate to severe mitral regurgitation at the time of transcatheter aortic valve replacement are at increased risk of future adverse events. Whether concomitant mitral regurgitation is independently associated with worse outcomes after TAVR remains a matter of debate. The optimal therapeutic strategy in these patients-TAVR with evidence-based heart failure therapy, combined TAVR and transcatheter mitral valve intervention, or staged transcatheter therapies-is ill-defined, and guideline-based recommendations in patients at increased risk for open heart surgery are lacking. Hence, a thorough evaluation of the aortic and mitral valve anatomy and function, along with an in-depth assessment of the patients' baseline risk profile, provides the basis for an individualized treatment approach. The aim of this review is therefore to give an overview of the current literature on mitral regurgitation in TAVR, focusing on different diagnostic and therapeutic strategies and optimal clinical decision making. Clinic for Cardiology zora Stähli Barbara E. joint author Reinthaler Markus joint author Leistner David M. joint author Landmesser Ulf joint author Lauten Alexander joint author Frontiers in cardiovascular medicine 5:74 https://www.zora.uzh.ch/id/eprint/166269/1/ZORA166269.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/166269/1/ZORA166269.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Stähli Barbara E. joint author ZORA 700 1- Reinthaler Markus joint author ZORA 700 1- Leistner David M. joint author ZORA 700 1- Landmesser Ulf joint author ZORA 700 1- Lauten Alexander joint author ZORA 773 0- Frontiers in cardiovascular medicine 5:74 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess