caa a22 4500 555311163 20200410031458.0 cr unu---uuuuu 190207e20180510xx s 000 0 eng 1471-2393 10.1186/s12884-018-1788-z doi (BORIS)oai:boris.unibe.ch:125737 610 ddc 29747591 pmid Misoprostol vaginal insert versus misoprostol vaginal tablets for the induction of labour: a cohort study [Elektronische Daten] [Daniele Bolla, Saskia Vanessa Weissleder, Anda-Petronela Radan, Maria Luisa Gasparri, Luigi Raio, Martin Müller, Daniel Surbek] publishedVersion openAccess eu-repo BACKGROUND Misoprostol vaginal insert for induction of labor has been recently reported to be superior to dinoprostone vaginal insert in a phase III trial, but has never been compared to vaginal misoprostol in another galenic form. The aim of this study was to compare misoprostol vaginal insert (MVI) with misoprostol vaginal tablets (MVT) for induction of labor in term pregnancies. METHODS In this retrospective cohort study we compared 200 consecutive women induced with 200-μg misoprostol 24-h vaginal insert (Misodel®) with a historical control of 200 women induced with Misoprostol 25-μg vaginal tablets (Cytotec®) every 4-6h. Main outcomes variables included induction-to-delivery interval, vaginal delivery within 24-h, incidence of tachysystole, mode of delivery, and neonatal outcome. A subanalysis in the MVI group was performed in order to identify predictive factors for tachysistole and vaginal delivery within 24h. RESULTS The time from induction to vaginal delivery was 1048 ±814min in the MVI group and 1510 ±1043min in the MVT group (p< 0.001). Vaginal delivery within 24-h occurred in 127 (63.5%) patients of the MVI group and in 110 (55%) patients of the MVT group (p< 0.001). Tachysystole was more common in the MVI group (36% vs. 18%; p< 0.001). However, no significant predictors of uterine tachysystole in MVI group have been identified in crude and fully adjusted logistic regression models. Bishop score was the only predictor for vaginal delivery within 24h (p< 0.001) in MVI group. Caesarean delivery rate (27% vs. 20%) and vaginal-operative deliveries (15.5% vs. 15.5%) did not differ significantly between the two groups. Neonatal outcomes were similar in both groups. CONCLUSIONS MVI achieves a more vaginal delivery rate within 24h and Tachysystole events compared to MVT. However, no differences in caesarean section, operative vaginal delivery, and neonatal outcomes are reported. No predictors of tachysistole after MVI administration have been identified. Bishop score and parity are the only predictors of vaginal delivery within 24h after MVI administration. Bolla Daniele joint author Weissleder Saskia Vanessa joint author Radan Anda-Petronela joint author Gasparri Maria Luisa joint author Raio Luigi joint author Müller Martin joint author Surbek Daniel joint author BMC pregnancy and childbirth 18(1), p. 149 1471-2393 https://boris.unibe.ch/125737/1/29747591.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/125737/1/29747591.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Bolla Daniele joint author BORIS 700 1- Weissleder Saskia Vanessa joint author BORIS 700 1- Radan Anda-Petronela joint author BORIS 700 1- Gasparri Maria Luisa joint author BORIS 700 1- Raio Luigi joint author BORIS 700 1- Müller Martin joint author BORIS 700 1- Surbek Daniel joint author BORIS 773 0- BMC pregnancy and childbirth 18(1), p. 149 1471-2393 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess