caa a22 4500 56920772X 20200410031433.0 cr unu---uuuuu 190724e20171025xx s 000 0 eng 1471-230X 10.1186/s12876-017-0670-1 doi (BORIS)oai:boris.unibe.ch:122923 360 ddc 510 ddc 610 ddc 29070010 pmid Longitudinal study of gastroesophageal reflux and erosive tooth wear [Elektronische Daten] [Clive H Wilder-Smith, Andrea Materna, Lukas Martig, Adrian Lussi] publishedVersion openAccess eu-repo BACKGROUND Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to characterize the longitudinal course of GERD and of associated erosive tooth wear, as well as factors predictive of its progression, in a large group of patients. METHODS Seventy-two patients presenting to dentists with clinically significant erosive tooth wear and increased esophageal acid exposure by 24-h multichannel intraluminal pH-impedance measurement (MII-pH) were re-assessed clinically and by MII-pH after 1year treatment with esomeprazole 20mg twice-daily. Predictive factors for erosive tooth wear were assessed by logistic regression. RESULTS At follow-up, no further progression in erosive tooth wear was observed in 53 (74%) of patients. The percentage of time with a pH<4, the number of acid reflux episodes and the percentage of proximal esophageal reflux off-PPI did not change significantly after one year, but the number of weakly acidic reflux episodes decreased significantly in the large subgroup without progression. None of the baseline demographic, clinical, endoscopic or esophageal acid exposure characteristics were significantly associated with progression of erosive tooth wear at follow-up. CONCLUSIONS In this longitudinal study in patients with erosive tooth wear and oligosymptomatic GERD receiving esomeprazole for one year, erosive tooth wear did not progress further in the majority of patients. Background acidic esophageal reflux exposure appeared stable over time, whereas weakly acidic exposure decreased significantly in patients without erosion progression. MII-pH measurements on-PPI and with healthy controls will be useful in the further elucidation of the causal role of reflux in erosive tooth wear. TRIAL REGISTRATION ClinicalTrials.gov , retrospectively registered: NCT02087345 . Wilder-Smith Clive H. joint author Materna Andrea joint author Martig Lukas joint author Lussi Adrian joint author BMC gastroenterology 17(1), p. 113 1471-230X https://boris.unibe.ch/122923/1/document%282%29.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/122923/1/document%282%29.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Wilder-Smith Clive H. joint author BORIS 700 1- Materna Andrea joint author BORIS 700 1- Martig Lukas joint author BORIS 700 1- Lussi Adrian joint author BORIS 773 0- BMC gastroenterology 17(1), p. 113 1471-230X BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess