caa a22 4500 569207789 20190729030202.0 cr unu---uuuuu 190724s2017 xx s 000 0 eng 1664-3224 10.3389/fimmu.2017.00353 doi (BORIS)oai:boris.unibe.ch:125417 610 ddc 28424689 pmid Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease [Elektronische Daten] [Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy] publishedVersion openAccess eu-repo Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions. Chemerin and a chemerin-derived antimicrobial peptide are bactericidal against select bacteria strategically positioned in dental biofilm. Gingival crevicular samples from patients with gingivitis but not periodontitis contain abundant bioactive chemerin capable of inducing CMKLR1-dependent leukocyte migration. Gingipains secreted by the periodontopathogen inactivate chemerin. Together, these data suggest that as an antimicrobial agent and leukocyte chemoattractant, chemerin likely contributes to antimicrobial immune defense in the oral cavity. Godlewska Urszula joint author Brzoza Piotr joint author Sroka Aneta joint author Majewski Pawel joint author Jentsch Holger joint author Eckert Martin joint author Eick Sigrun joint author Potempa Jan joint author Zabel Brian A. joint author Cichy Joanna joint author Frontiers in immunology 8, p. 353 1664-3224 https://boris.unibe.ch/125417/1/fimmu-08-00353.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/125417/1/fimmu-08-00353.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Godlewska Urszula joint author BORIS 700 1- Brzoza Piotr joint author BORIS 700 1- Sroka Aneta joint author BORIS 700 1- Majewski Pawel joint author BORIS 700 1- Jentsch Holger joint author BORIS 700 1- Eckert Martin joint author BORIS 700 1- Eick Sigrun joint author BORIS 700 1- Potempa Jan joint author BORIS 700 1- Zabel Brian A. joint author BORIS 700 1- Cichy Joanna joint author BORIS 773 0- Frontiers in immunology 8, p. 353 1664-3224 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess