caa a22 4500 569242444 20191025051757.0 cr unu---uuuuu 190725e201708 xx s 000 0 eng 0905-7161 10.1111/clr.12912 doi (BORIS)oai:boris.unibe.ch:123767 610 ddc 27333829 pmid Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses [Elektronische Daten] [Simon Meyer, Catherine Giannopoulou, Delphine Courvoisier, Martin Schimmel, Frauke Müller, Andrea Mombelli] publishedVersion openAccess eu-repo OBJECTIVES To compare in persons aged 70years or older the clinical and inflammatory changes occurring around implants and natural teeth during and after a phase of undisturbed plaque accumulation. MATERIAL AND METHODS Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored for 3weeks. Twelve biomarkers were assessed in gingival and peri-implant crevicular fluid (GCF, PCF). RESULTS During 3weeks of oral hygiene abstention, the gingival index (GI) continuously increased. On day 21, there were significantly more sites with GI >1 at implants than at teeth. After restarting oral hygiene, the GI decreased markedly in both groups. Throughout the experiment, the plaque index was significantly higher on teeth than on implants. The different biomarkers reacted variably. IL-1β increased significantly with plaque accumulation. IL-1β, GM-CSF, TNF-α, and IFN-γ were significantly higher in GCF compared to PCF at day 21. IL-8 decreased significantly in GCF up to day 14. MIP-1β decreased significantly in GCF, but not in PCF. At the 3-week follow-up, the levels of all biomarkers assessed in GCF and PCF had returned to baseline values. CONCLUSIONS In an elderly cohort, plaque accumulation induced an inflammatory reaction around both teeth and implants. Although there was less plaque accumulation on implants, the peri-implant mucosa showed a stronger clinical response than gingiva. Meyer Simon joint author Giannopoulou Catherine joint author Courvoisier Delphine joint author Schimmel Martin joint author Müller Frauke joint author Mombelli Andrea joint author Clinical oral implants research 28(8), pp. 1005-1012 0905-7161 353835196 https://boris.unibe.ch/123767/2/Meyer_et_al-2017-Clinical_Oral_Implants_Research.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/123767/2/Meyer_et_al-2017-Clinical_Oral_Implants_Research.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Meyer Simon joint author BORIS 700 1- Giannopoulou Catherine joint author BORIS 700 1- Courvoisier Delphine joint author BORIS 700 1- Schimmel Martin joint author BORIS 700 1- Müller Frauke joint author BORIS 700 1- Mombelli Andrea joint author BORIS 773 0- Clinical oral implants research 28(8), pp. 1005-1012 0905-7161 353835196 BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess