naa a22 4500 569250757 20190725055454.0 cr unu---uuuuu 190725e201907 xx s 100 0 eng 10.3929/ethz-b-000354209 doi 10.2903/j.efsa.2019.e170712 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/354209 Advancing human health risk assessment [Elektronische Daten] [Anna Lanzoni, Anna F. Castoldi, George E.N. Kass, Andrea Terron, Guilhem De Seze, Anna Bal‐Price, Frédéric Y. Bois, K. Barry Delclos, Daniel R. Doerge, Ellen Fritsche, Thorhallur Halldorsson, Marike Kolossa-Gehring, Susanne Hougaard Bennekou, Frits Koning, Alfonso Lampen, Marcel Leist, Ellen Mantus, Christophe Rousselle, Michael Siegrist, Pablo Steinberg, Angelika Tritscher, Bob Van de Water, Paolo Vineis, Nigel Walker, Heather Wallace, Maurice Whelan, Maged Younes, Yann Devos (Editor), Kevin Elliott (Editor), Anthony Hardy (Editor)] Oxford Wiley 2019 21 p. Open access ethresearch The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science - Human health' at EFSA's third Scientific Conference ‘Science, Food and Society' (Parma, Italy, 18-21 September 2018). The Third EFSA Scientific Conference: Science, Food and Society (EFSA 2018) in Parma, Italy (September 18-21, 2018) Creative Commons Attribution-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nd/4.0 ethresearch Alternative methods ethresearch Exposure ethresearch Epidemiology ethresearch Food safety ethresearch Mechanistic studies ethresearch Risk assessment ethresearch Lanzoni Anna joint author Castoldi Anna F. joint author Kass George E.N. joint author Terron Andrea joint author De Seze Guilhem joint author Bal‐Price Anna joint author Bois Frédéric Y. joint author Delclos K. Barry joint author Doerge Daniel R. joint author Fritsche Ellen joint author Halldorsson Thorhallur joint author Kolossa-Gehring Marike joint author Hougaard Bennekou Susanne joint author Koning Frits joint author Lampen Alfonso joint author Leist Marcel joint author Mantus Ellen joint author Rousselle Christophe joint author Siegrist Michael joint author Steinberg Pablo joint author Tritscher Angelika joint author Van de Water Bob joint author Vineis Paolo joint author Walker Nigel joint author Wallace Heather joint author Whelan Maurice joint author Younes Maged joint author Devos Yann Editor edt Elliott Kevin Editor edt Hardy Anthony Editor edt Proceedings of the Third EFSA Scientific Conference: Science, Food and Society Oxford : Wiley p. e170712 http://hdl.handle.net/20.500.11850/354209 text/html WWW-Backlink auf das Repository (Open access) 1 Conference Paper ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/354209 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Lanzoni Anna joint author ETHRESEARCH 700 1- Castoldi Anna F. joint author ETHRESEARCH 700 1- Kass George E.N. joint author ETHRESEARCH 700 1- Terron Andrea joint author ETHRESEARCH 700 1- De Seze Guilhem joint author ETHRESEARCH 700 1- Bal‐Price Anna joint author ETHRESEARCH 700 1- Bois Frédéric Y. joint author ETHRESEARCH 700 1- Delclos K. Barry joint author ETHRESEARCH 700 1- Doerge Daniel R. joint author ETHRESEARCH 700 1- Fritsche Ellen joint author ETHRESEARCH 700 1- Halldorsson Thorhallur joint author ETHRESEARCH 700 1- Kolossa-Gehring Marike joint author ETHRESEARCH 700 1- Hougaard Bennekou Susanne joint author ETHRESEARCH 700 1- Koning Frits joint author ETHRESEARCH 700 1- Lampen Alfonso joint author ETHRESEARCH 700 1- Leist Marcel joint author ETHRESEARCH 700 1- Mantus Ellen joint author ETHRESEARCH 700 1- Rousselle Christophe joint author ETHRESEARCH 700 1- Siegrist Michael joint author ETHRESEARCH 700 1- Steinberg Pablo joint author ETHRESEARCH 700 1- Tritscher Angelika joint author ETHRESEARCH 700 1- Van de Water Bob joint author ETHRESEARCH 700 1- Vineis Paolo joint author ETHRESEARCH 700 1- Walker Nigel joint author ETHRESEARCH 700 1- Wallace Heather joint author ETHRESEARCH 700 1- Whelan Maurice joint author ETHRESEARCH 700 1- Younes Maged joint author ETHRESEARCH 700 1- Devos Yann Editor edt ETHRESEARCH 700 1- Elliott Kevin Editor edt ETHRESEARCH 700 1- Hardy Anthony Editor edt ETHRESEARCH 773 0- Proceedings of the Third EFSA Scientific Conference: Science, Food and Society Oxford : Wiley p. e170712 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Conference Paper Open access