cad a22 4500 569274524 20200608052103.0 cr unu---uuuuu 190725e20190901xx s 000 0 eng 10.5167/uzh-171616 doi 10.1111/clr.13492 doi (ZORA)oai:www.zora.uzh.ch:171616 610 ddc 31172607 pmid Randomized clinical study using xenograft blocks loaded with bone morphogenetic protein‐2 or autogenous bone blocks for ridge augmentation - a three‐dimensional analysis [Elektronische Daten] [Daniel S Thoma, Stefan P Bienz, Michael Payer, Jürg Hüsler, Patrick R Schmidlin, Christoph H F Hämmerle, Norbert Jakse, Ronald E Jung] openAccess eu-repo OBJECTIVES: To test whether or not the use of a xenogeneic block loaded with rhBMP-2 results in superior radiological and profilometric outcomes compared to an autogenous bone block. MATERIALS AND METHODS: Twenty-four patients randomly received a xenogeneic block loaded with rhBMP-2 (test) or an autogenous bone block (control) for primary augmentation. The ridge width (RW) was evaluated by means of a CBCT scan after augmentation surgery and at 4 months, prior to implant placement. Surface scans were taken prior to augmentation and at 4 months for profilometric analyses. Data were analyzed with Wilcoxon-signed rank test, Mann-Whitney test, or nonparametric ANOVA models. RESULTS: The median RW after augmentation amounted to 7.13 mm (Q1 = 6.02; Q3 = 8.47) for test and 6.86 mm (Q1 = 5.99; Q3 = 8.95) for control. During 4 months of healing, the total RW decreased statistically significantly and measured 5.35 mm (Q1 = 4.53; Q3 = 6.7) for test and 5.15 mm (Q1 = 3.57; Q3 = 7.24) for control (p = 0.0005). The differences between the groups were not statistically significant (p > 0.5899). The buccal soft tissue contour slightly increased for test (0.83 mm; Q1 = 0.62; Q3 = 1.87) and control (1.16 mm; Q1 = 0.50; Q3 = 1.44). CONCLUSIONS: Both treatment modalities successfully increased the ridge width to a similar extent. The shrinkage during healing was not greater in the test than in the control group. The impact of hard tissue augmentation on the soft tissue contour was, however, minimal. Clinic of Conservative and Preventive Dentistry zora Clinic of Reconstructive Dentistry zora Oral Surgery zora Thoma Daniel S. joint author Bienz Stefan P. joint author Payer Michael joint author Hüsler Jürg joint author Schmidlin Patrick R. joint author Hämmerle Christoph H F. joint author Jakse Norbert joint author Jung Ronald E. joint author Clinical Oral Implants Research 30(9):872-881 https://www.zora.uzh.ch/id/eprint/171616/1/Thoma_et_al-2019-Clinical_Oral_Implants_Research_acc.pdf text/html WWW-Backlink auf das Repository BK010053 XK010053 XK010000 1 Journal Article PeerReviewed zora ZORA ZORA ZORA Journal Article openAccess ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171616/1/Thoma_et_al-2019-Clinical_Oral_Implants_Research_acc.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Thoma Daniel S. joint author ZORA 700 1- Bienz Stefan P. joint author ZORA 700 1- Payer Michael joint author ZORA 700 1- Hüsler Jürg joint author ZORA 700 1- Schmidlin Patrick R. joint author ZORA 700 1- Hämmerle Christoph H F. joint author ZORA 700 1- Jakse Norbert joint author ZORA 700 1- Jung Ronald E. joint author ZORA 773 0- Clinical Oral Implants Research 30(9):872-881