nad a22 4500 569274575 20190725055513.0 cr unu---uuuuu 190725e20190525xx s 000 0 eng 10.5167/uzh-171625 doi 10.1016/j.plipres.2019.100988 doi (ZORA)oai:www.zora.uzh.ch:171625 610 ddc 540 ddc 31132366 pmid Mammalian sphingoid bases: Biophysical, physiological and pathological properties [Elektronische Daten] [A C Carreira, T C Santos, M A Lone, E Zupančič, E Lloyd-Evans, R F M de Almeida, T Hornemann, L C Silva] closedAccess eu-repo Sphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules, and have been associated with numerous biological and physiological processes. In addition, they can modulate the biophysical properties of biological membranes. Several human diseases are related to pathological changes in the structure and metabolism of sphingoid bases. Yet, the mechanisms underlying their biological and pathophysiological actions remain elusive. Within this review, we aimed to summarize the current knowledge on the biochemical and biophysical properties of the most common sphingoid bases and to discuss their importance in health and disease. Institute of Clinical Chemistry zora Carreira A C. joint author Santos T C. joint author Lone M A. joint author Zupančič E. joint author Lloyd-Evans E. joint author de Almeida R F M. joint author Hornemann T. joint author Silva L C. joint author Progress in Lipid Research 75:100988 https://www.zora.uzh.ch/id/eprint/171625/1/1-s2.0-S0163782718300651-main.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171625/1/1-s2.0-S0163782718300651-main.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Carreira A C. joint author ZORA 700 1- Santos T C. joint author ZORA 700 1- Lone M A. joint author ZORA 700 1- Zupančič E. joint author ZORA 700 1- Lloyd-Evans E. joint author ZORA 700 1- de Almeida R F M. joint author ZORA 700 1- Hornemann T. joint author ZORA 700 1- Silva L C. joint author ZORA 773 0- Progress in Lipid Research 75:100988 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article closedAccess