nad a22 4500 569302854 20190726063007.0 cr unu---uuuuu 190726e201904 xx s 000 0 eng 10.5167/uzh-171633 doi 10.1007/s11789-019-00101-8 doi (ZORA)oai:www.zora.uzh.ch:171633 610 ddc 540 ddc 30838553 pmid Nave Alexander Heinrich Is lipoprotein(a) arisk factor for ischemic stroke and venous thromboembolism? [Elektronische Daten] [Alexander Heinrich Nave, Arnold von Eckardstein] openAccess eu-repo The structural similarity with plasminogen as well as thrombogenic and atherogenic in vitro functions raise the question if lipoprotein(a) (Lp(a)) is arisk factor for venous thromboembolism (VTE) and ischemic stroke. Numerous case-control and prospective studies using different cut-off values to define high Lp(a) generated conflicting evidence for both VTE and ischemic stroke. Several meta-analyses demonstrated independent associations of elevated Lp(a) with ahistory of VTE or ischemic stroke. However, the evidence of prospective studies for associations of Lp(a) with incident stroke or recurrent VTE remains inconclusive. For ischemic stroke, data suggest that Lp(a) increases the risk of large-artery atherosclerosis stroke, but not cardioembolic or lacunar stroke. Lp(a) may increase the risk of VTE in the presence of additional thrombophilic risk factors. Larger cohort studies are needed to elaborate the importance of higher Lp(a) cut-offs and interactions with other risk factors and subgroups of stroke or VTE. The value of Lp(a) to estimate residual vascular risk after the first thromboembolic event remains to be adequately explored. Institute of Clinical Chemistry zora von Eckardstein Arnold joint author Clinical Research in Cardiology Supplements 14(Suppl 1):28-32 https://www.zora.uzh.ch/id/eprint/171633/1/s11789-019-00101-8.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171633/1/s11789-019-00101-8.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Nave Alexander Heinrich ZORA 700 1- von Eckardstein Arnold joint author ZORA 773 0- Clinical Research in Cardiology Supplements 14(Suppl 1):28-32 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess