cad a22 4500 569302897 20200603055951.0 cr unu---uuuuu 190726e20200601xx s 000 0 eng 10.5167/uzh-171660 doi 10.1016/j.biopsych.2019.04.022 doi (ZORA)oai:www.zora.uzh.ch:171660 610 ddc 31178097 pmid Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium [Elektronische Daten] [Xiang-Zhen Kong, Premika S W Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Paul D Arnold, Francesca Assogna, Justin T Baker, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A Ely, Jamie Feusner, Kate D Fitzgerald, Jean-Paul Fouche, Egill A Fridgeirsson, David C Glahn, Patricia Gruner, Deniz A Gürsel, Tobias U Hauser, Oana Georgiana Rus-Oswald, et al] restrictedAccess eu-repo BACKGROUND Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. RESULTS In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d= 0.19) and the pallidum (less leftward; d=-0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. CONCLUSIONS The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD. Clinic for Neuroradiology zora Department of Child and Adolescent Psychiatry zora Neuroscience Center Zurich zora Kong Xiang-Zhen joint author Boedhoe Premika S W. joint author Abe Yoshinari joint author Alonso Pino joint author Ameis Stephanie H. joint author Arnold Paul D. joint author Assogna Francesca joint author Baker Justin T. joint author Batistuzzo Marcelo C. joint author Benedetti Francesco joint author Beucke Jan C. joint author Bollettini Irene joint author Bose Anushree joint author Brem Silvia joint author Brennan Brian P. joint author Buitelaar Jan joint author Calvo Rosa joint author Cheng Yuqi joint author Cho Kang Ik K. joint author Dallaspezia Sara joint author Denys Damiaan joint author Ely Benjamin A. joint author Feusner Jamie joint author Fitzgerald Kate D. joint author Fouche Jean-Paul joint author Fridgeirsson Egill A. joint author Glahn David C. joint author Gruner Patricia joint author Gürsel Deniz A. joint author Hauser Tobias U. joint author Rus-Oswald Oana Georgiana joint author et al joint author Biological Psychiatry 87(12):1022-1034 https://www.zora.uzh.ch/id/eprint/171660/1/Kong_et_al_2019_Mapping_Cortical_and_Subcortical_Asymmetry_in.pdf text/html WWW-Backlink auf das Repository BK010053 XK010053 XK010000 1 Journal Article PeerReviewed zora ZORA ZORA ZORA Journal Article restrictedAccess ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171660/1/Kong_et_al_2019_Mapping_Cortical_and_Subcortical_Asymmetry_in.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Kong Xiang-Zhen joint author ZORA 700 1- Boedhoe Premika S W. joint author ZORA 700 1- Abe Yoshinari joint author ZORA 700 1- Alonso Pino joint author ZORA 700 1- Ameis Stephanie H. joint author ZORA 700 1- Arnold Paul D. joint author ZORA 700 1- Assogna Francesca joint author ZORA 700 1- Baker Justin T. joint author ZORA 700 1- Batistuzzo Marcelo C. joint author ZORA 700 1- Benedetti Francesco joint author ZORA 700 1- Beucke Jan C. joint author ZORA 700 1- Bollettini Irene joint author ZORA 700 1- Bose Anushree joint author ZORA 700 1- Brem Silvia joint author ZORA 700 1- Brennan Brian P. joint author ZORA 700 1- Buitelaar Jan joint author ZORA 700 1- Calvo Rosa joint author ZORA 700 1- Cheng Yuqi joint author ZORA 700 1- Cho Kang Ik K. joint author ZORA 700 1- Dallaspezia Sara joint author ZORA 700 1- Denys Damiaan joint author ZORA 700 1- Ely Benjamin A. joint author ZORA 700 1- Feusner Jamie joint author ZORA 700 1- Fitzgerald Kate D. joint author ZORA 700 1- Fouche Jean-Paul joint author ZORA 700 1- Fridgeirsson Egill A. joint author ZORA 700 1- Glahn David C. joint author ZORA 700 1- Gruner Patricia joint author ZORA 700 1- Gürsel Deniz A. joint author ZORA 700 1- Hauser Tobias U. joint author ZORA 700 1- Rus-Oswald Oana Georgiana joint author ZORA 700 -- et al joint author ZORA 773 0- Biological Psychiatry 87(12):1022-1034